Opioid-Free anesthesia: a safer way to go under the knife?
NCT ID NCT06380244
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares opioid-free anesthesia to standard opioid-based anesthesia in 600 adults undergoing urological abdominal surgery. The goal is to see if avoiding opioids during surgery reduces the need for painkillers afterward and lowers side effects like nausea. Patients will be followed for 24 hours after their operation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
opioid-free anesthesia (dexmedetomidine, ketamine, lidocaine, NSAIDs, regional analgesia)
What this could lead to
If successful, this could offer a safer way to manage pain during surgery, reducing opioid use and related side effects like nausea and vomiting.
What could go wrong
This is an early-stage study with 600 patients, and results may not apply to all surgeries. The opioid-free approach might not control pain as well as standard methods.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Jagiellonian University
RECRUITINGKrakow, Lesser Poland Voivodeship, 31501, Poland
Contact Phone: •••-•••-•••• Email: •••••@•••••