Opioid-Free anesthesia: a safer way to go under the knife?

NCT ID NCT06380244

Recruiting now Symptom relief Sponsor: Jagiellonian University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares opioid-free anesthesia to standard opioid-based anesthesia in 600 adults undergoing urological abdominal surgery. The goal is to see if avoiding opioids during surgery reduces the need for painkillers afterward and lowers side effects like nausea. Patients will be followed for 24 hours after their operation.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: opioid-free anesthesia (dexmedetomidine, ketamine, lidocaine, NSAIDs, regional analgesia)
What this could lead to: If successful, this could offer a safer way to manage pain during surgery, reducing opioid use and related side effects like nausea and vomiting.
What could go wrong: This is an early-stage study with 600 patients, and results may not apply to all surgeries. The opioid-free approach might not control pain as well as standard methods.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

urinary system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANALGESICS, OPIOID ANESTHESIA, ENDOTRACHEAL ANESTHESIA, GENERAL

Contacts and locations

Locations

Jagiellonian University
RECRUITING

Krakow, Lesser Poland Voivodeship, 31501, Poland

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