Can a nausea drug stop propofol pain? new trial investigates

NCT ID NCT07632144

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial compares ondansetron (a common anti-nausea drug) against lidocaine and a placebo for preventing pain when propofol is injected to start anesthesia. About 156 adults having elective surgery will be randomly assigned to one of three groups. The goal is to see if ondansetron reduces the number of people who feel pain and how intense that pain is.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

ondansetron

What this could lead to

If it works, ondansetron could offer a new option to ease injection pain during anesthesia induction.

What could go wrong

This is a small, early-stage trial with only 156 participants, so results may not apply widely. The effect may be no better than lidocaine or placebo.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for ANESTHESIA INDUCTION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Mongi Slim Hospital

    Tunis, 2046, Tunisia

    Contact Email: •••••@•••••

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact