Experimental virus therapy takes on deadly brain tumors
NCT ID NCT07472790
First seen Jun 26, 2026 · Last updated Jul 15, 2026 · Updated 3 times
Summary
This early-stage trial tests a new treatment for recurrent high-grade glioma, an aggressive brain cancer. The approach uses a specially designed virus injected directly into the tumor to kill cancer cells and boost the immune system, combined with a PD-1 inhibitor drug that helps the immune system attack the cancer. The study will enroll 15 adults whose cancer has returned after standard treatment, to see if the combination is safe and how long they live.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- oncolytic virus Ad-TD-nsIL12 combined with a PD-1 inhibitor
- What this could lead to
- If successful, this could point toward a new treatment option for recurrent high-grade glioma, a brain cancer with few effective therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 15 people, so it is too soon to know if the combination works or is safe. The virus and immune drug may cause serious side effects, and the cancer may still progress.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sanbo Brain Hospital, Capital Medical University
Beijing, Chaoyang District, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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