New frown line injection shows promise in early trial
NCT ID NCT05100199
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested a new botulinum toxin injection (OnabotulinumtoxinA X) for treating moderate to severe frown lines between the eyebrows. 328 adults received either the active injection or a placebo. Researchers measured wrinkle improvement and tracked any side effects. The goal was to find the best dose and confirm safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- OnabotulinumtoxinA X (a botulinum toxin type A injection)
- What this could lead to
- If successful, this could lead to a new treatment option for reducing frown lines between the eyebrows.
- What could go wrong
- This is an early Phase 2 dose-ranging study, so results may not confirm effectiveness or safety. Side effects like injection site reactions or muscle weakness are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Advanced Research Associates - Glendale /ID# 230418
Glendale, Arizona, 85308, United States
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Aesthetic Solutions /ID# 230716
Chapel Hill, North Carolina, 27517-9901, United States
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Aventiv Research Dublin /ID# 232546
Dublin, Ohio, 43016, United States
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Baumann Cosmetic and Research Institute /ID# 232545
Miami, Florida, 33137-3254, United States
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Center for Dermatology and Dermatologic Surgery /ID# 230684
Washington D.C., District of Columbia, 20037-1445, United States
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Coleman Center For Cosmetic Dermatologic Surgery /ID# 230693
Metairie, Louisiana, 70006, United States
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Etre Cosmetic Dermatology and Laser Center /ID# 230437
New Orleans, Louisiana, 70130-4353, United States
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Laser & Skin Surgery Center of New York /ID# 230683
New York, New York, 10016-4974, United States
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Premier Clinical Research /ID# 230682
Spokane, Washington, 99202, United States
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Research Institute of the Southeast, LLC /ID# 230436
West Palm Beach, Florida, 33401-2712, United States
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SLUCare Cosmetic Dermatology /ID# 230333
St Louis, Missouri, 63122-3379, United States
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Skin Search of Rochester Inc. /ID# 242540
Rochester, New York, 14623, United States
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Steven Fagien MD Aesthetic Eyelid Plastic Surgery /ID# 232542
Boca Raton, Florida, 33431-6465, United States
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The Eye Research Foundation /ID# 232544
Newport Beach, California, 92663-3637, United States
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The Research Center at The Maas Clinic /ID# 230685
San Francisco, California, 94115-1809, United States
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Westlake Dermatology & Cosmetic Surgery - Westlake /ID# 232543
Austin, Texas, 78746-4720, United States
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Westside Aesthetics /ID# 230305
Los Angeles, California, 90025-1708, United States
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Wilmington Dermatology Center /ID# 242544
Wilmington, North Carolina, 28403, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- New combo treatment targets Crow's feet and hollow eyes