New drug combo aims to stall advanced prostate cancer

NCT ID NCT03787680

Ongoing Disease control Sponsor: University of Michigan Rogel Cancer Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a combination of two drugs, olaparib and AZD6738, can shrink tumors or lower PSA levels in men with advanced prostate cancer that no longer responds to hormone therapy. About 49 men with metastatic castration-resistant prostate cancer will receive the drug combo. The goal is to see if the treatment can control the disease, especially in men whose tumors have certain DNA repair features.

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Conditions

The condition(s) this trial relates to.

castration-resistant prostate carcinoma metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROSTATE CANCER

Contacts and locations

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Locations

University of Michigan Hospital

Ann Arbor, Michigan, 48109, United States
University of Virginia Health System

Charlottesville, Virginia, 22908, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States