New drug duo targets genetic weakness in Tough-to-Treat cancers
NCT ID NCT03878095
Summary
This study is testing whether two oral drugs, olaparib and ceralasertib (AZD6738), can help control advanced solid tumors that have a specific genetic change called an IDH mutation and have stopped responding to standard therapies. It is for adults with cancers like cholangiocarcinoma (bile duct cancer) and other solid tumors. The main goal is to see if the drug combination can shrink tumors or stop them from growing.
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Contacts and locations
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Locations
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah, 84112, United States
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland, 21287, United States
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M D Anderson Cancer Center
Houston, Texas, 77030, United States
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Northwestern University
Chicago, Illinois, 60611, United States
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Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210, United States
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Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut, 06510, United States
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Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut, 06611, United States
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UF Health Cancer Institute - Gainesville
Gainesville, Florida, 32610, United States
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University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, 35233, United States
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin, 53792, United States
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Wayne State University/Karmanos Cancer Institute
Detroit, Michigan, 48201, United States
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Weisberg Cancer Treatment Center
Farmington Hills, Michigan, 48334, United States
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Yale University
New Haven, Connecticut, 06520, United States
Conditions
Explore the condition pages connected to this study.