New hope for kids with MS: major drug showdown begins
NCT ID NCT05123703
First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times
Summary
This study tests whether ocrelizumab is safer and more effective than fingolimod for children and adolescents (ages 10 to under 18) with relapsing-remitting multiple sclerosis. Participants receive either drug and are monitored for relapses and brain lesions over at least 24 weeks. The goal is to find a better treatment option to control this chronic disease.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Astra Kliinik
Tallinn, 11315, Estonia
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Azienda Ospedaliera Sant'Andrea
Rome, Lazio, 00189, Italy
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Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele
Catania, Sicily, 95123, Italy
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Azienda Ospedaliero-Universitaria Consorziale Pol. di Bari
Bari, Apulia, 70124, Italy
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Baylor College of Medicine/Texas Children's Hospital
Houston, Texas, 77030-2608, United States
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Boston Children's Hospital Central Pharmacy
Boston, Massachusetts, 02115-5724, United States
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CHRU de Montpellier, Hopital Gui de Chauliac
Montpellier, 34295, France
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CHU Mohammed VI
Marrakesh, 40000, Morocco
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CPQuali Pesquisa Clínica Sao Paulo
São Paulo, São Paulo, 01228-000, Brazil
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Centre Hospitalier Universitaire de Bicêtre
Le Kremlin-Bicêtre, 94275, France
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Centro de Investigacion Clinica Chapultepec S. A. de C. V.
Morelia, Michoacán, 58260, Mexico
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Centro de Investigaciones Médicas Tucuman
San Miguel de Tucumán, T4000AXL, Argentina
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Children's Clinical University Hospital
Riga, LV-1004, Latvia
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Children's Hospital Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1, Canada
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Children's National Hospital
Washington D.C., District of Columbia, 20010, United States
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Childrens University Hospital
Belgrade, 11000, Serbia
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Cleveland Clinic, Mellen Center for Multiple Sclerosis
Cleveland, Ohio, 44195-0001, United States
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Clinic for Neurology and Psychiatry for Children and Youth
Belgrade, 11000, Serbia
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Clinstile S.A de C.V.
Mexico City, Mexico CITY (federal District), 06700, Mexico
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Communal noncommercial enterprise of Lviv Regional Council Lviv Regional Clinical Hospital
Lviv, Kharkiv Governorate, 79010, Ukraine
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Debreceni Egyetem Klinikai Kozpont
Debrecen, H-4032, Hungary
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Dzieci?cy Szpital Kliniczny im. Józefa Polikarpa Brudzi?skiego
Warsaw, 02-091, Poland
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Eginitio University General Hospital of Athens
Athens, Attica, 115 28, Greece
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FAICIC S de R.L. de C.V
Veracruz, 91900, Mexico
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Fondazione IRCCS Istituto Neurologico Carlo Besta
Milan, Lombardy, 20133, Italy
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Grupo Médico Camino S.C.
Mexico City, Mexico CITY (federal District), 3310, Mexico
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Hopital de Hautepierre
Strasbourg, 67091, France
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Hospices Civils de Lyon - Hôpital Pierre Wertheimer
Bron, Rhône, 69003, France
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Hospital Civil Fray Antonio Alcalde
Guadalajara, Jalisco, 44280, Mexico
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Hospital Sant Joan De Deu
Esplugues de Llobregas, Barcelona, 08950, Spain
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Hospital Santo Antonio dos Capuchos
Lisbon, 1169-050, Portugal
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Hospital Sao Lucas - PUCRS
Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
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Hospital Universitari Vall d'Hebron
Barcelona, 08035, Spain
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Hospital Universitario Ramon y Cajal
Madrid, 28034, Spain
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Hospital Universitario Virgen Macarena
Seville, 41009, Spain
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Hospital Universitario de la Princesa
Madrid, 28006, Spain
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Hospital de Braga
Braga, 4710-243, Portugal
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Inst. Da Criança- Faculdade de Medicina Usp
São Paulo, 05403-900, Brazil
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Instituto de Neurologia de Curitiba
Curitiba, Paraná, 81210-310, Brazil
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Instytut Pomnik Centrum Zdrowia Dziecka
Warsaw, 04-730, Poland
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Johns Hopkins Medicine
Baltimore, Maryland, 21287, United States
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L2 Ip - Instituto de Pesquisas Clinicas Ltda - ME
Brasília, Federal District, 70200-730, Brazil
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Medizinische Universität Wien
Vienna, 1090, Austria
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Mother and Child Health Care Institute of Serbia Dr Vukan Cupic
Belgrade, 11000, Serbia
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Neurociencias Estudios Clinicos S.C.
Culiacán, Sinaloa, 80020, Mexico
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Nucleo de Pesquisa Clinica do Rio Grande do Sul NPCR
Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
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Ospedale Pediatrico Bambino Gesù
Rome, Lazio, 00165, Italy
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Prof Dr Alexandru Obregia Clinical Psychiatric Hospital
Bucharest, 041914, Romania
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Royal Children's Hospital Melbourne - PIN
Parkville, Victoria, 3052, Australia
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Royal Hospital for Children and Young People
Edinburgh, EH51, United Kingdom
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Semmelweis Egyetem
Budapest, 1094, Hungary
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Sparsh Super Speciality Hospital
Bangalore North, Karnataka, 560022, India
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St. Luke's Hospital
Thessaloniki, 552 36, Greece
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Tartu University Hospital
Tartu, 50406, Estonia
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The Boster Center for Multiple Sclerosis a Singlepoint Healthcare Company
Columbus, Ohio, 43235, United States
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The Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104-4319, United States
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The Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
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UC San Diego
La Jolla, California, 92037-1337, United States
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ULS de Coimbra, EPE - Hospitais da Universidade de Coimbra
Coimbra, 3000-602, Portugal
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UZ Gent
Ghent, 9000, Belgium
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Universita? G. D'Annunzio
Chieti, Abruzzo, 66100, Italy
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Universitaetsklinikum Carl Gustav Carus an der TU Dresden
Dresden, 01307, Germany
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University Clinical Centre of Nis
Niš, 18000, Serbia
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University General Hospital ''ATTIKON'' - General Hospital of West Attica H AGIA VARVARA
Chaïdári, Attica, 124 62, Greece
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Universitäts-Kinderspital Zürich - Eleonorenstiftung
Zurich, 8008, Switzerland
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Uniwersytecki Szpital Kliniczny w Poznaniu
Późna, 60-355, Poland
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Uniwersyteckie Centrum Kliniczne
Gda?sk, 80-952, Poland
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Vestische Kinder- und Jugendklinik Datteln
Datteln, 45711, Germany
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Victor Gomoiu Clinical Hospital for Children
Bucharest, 022102, Romania
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Washington University
St Louis, Missouri, 63101, United States
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