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Brain scans and biosamples: mapping why OCD looks so different in every person

NCT ID NCT07822516

Knowledge-focused Sponsor: Shanghai Mental Health Center Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 16, 2026 · Last updated Sep 17, 2026 · Updated 1 time

Summary

Researchers at Shanghai Mental Health Center are following 500 people with obsessive-compulsive disorder to see how symptoms, daily functioning, and treatment responses change over time. The study includes adults aged 18 to 60, including some who have never received OCD treatment. Participants complete clinical interviews, neuropsychological tests, brain imaging, and provide blood and stool samples. The goal is to learn whether these combined measures can explain why OCD varies so much between people and predict who will respond to which treatments.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the study succeeds, it could help doctors predict which OCD treatments work best for which people and explain why symptoms differ so much between patients.
What could go wrong
This is an observational study, so it cannot prove cause and effect. Results may not apply to everyone with OCD, and long-term follow-up can lose participants over time.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited from clinical outpatient and inpatient units at Shanghai Mental Health Center. The study population consists of adult patients diagnosed with obsessive-compulsive disorder seeking routine clinical care. No investigator-assigned treatments are provided.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 【First-episode obsessive-compulsive disorder subgroup】 * Aged 18-60 years, no restriction on sex; * Meets DSM-5 diagnostic criteria for obsessive-compulsive disorder; * Junior high-school education or above; able to understand study-related information and complete questionnaires and examinations; * Has never received pharmacotherapy, psychological therapy or physical intervention for OCD; * Voluntarily participates in this study and provides written informed consent. 【Initial-treatment non-responder subgroup】 * Aged 18-60 years, no restriction on sex; * Meets DSM-5 diagnostic criteria for obsessive-compulsive disorder; * Junior high-school education or above; able to understand study-related information and complete questionnaires and examinations; * Has shown poor treatment response or intolerance after adequate-dose and adequate-duration treatment with one SSRI/SNRI agent, OR after receiving 12 sessions of cognitive-behavioral therapy (CBT); * Voluntarily participates in this study and provides written informed consent. 【Pharmacotherapy-resistant subgroup】 * Aged 18-60 years, no restriction on sex; * Meets DSM-5 diagnostic criteria for obsessive-compulsive disorder; * Junior high-school education or above; able to understand study-related information and complete questionnaires and examinations; * Demonstrates poor treatment response or intolerance following adequate-dose and adequate-duration treatment with two or more different SSRI/SNRI agents; * Voluntarily participates in this study and provides written informed consent. Exclusion Criteria: * Meets the diagnosis criteria in DSM-5 except for obsessive-compulsive disorder (excluding obsessive-compulsive personality disorder); * The obsessive symptoms are severe and prevent the patient from completing the required assessment tests; * Pregnant or women who are about to become pregnant, lactating women; * Have severe negative thoughts or a high risk of suicide; * Have a history of other substance dependence or excessive use in the past year; 6) Other situations deemed unsuitable for inclusion by the researchers.

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive disorder obsessive-compulsive personality disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obsessive compulsive disorder

How to take part

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  1. The official record

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    Open the record ↗

  2. A doctor treating you

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