New drug aims to stop Flare-Ups in rare autoimmune disease
NCT ID NCT05662241
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a drug called obexelimab to see if it can prevent flare-ups in people with IgG4-related disease, a rare condition where the immune system attacks the body's own tissues. About 194 adults with active disease will receive either the drug or a placebo. The main goal is to measure how long it takes for a flare to occur over one year.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Ajou University Hospital
Suwon, 206, South Korea
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Artus Health Centre
Vancouver, British Columbia, Canada
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Azienda Ospedaliera Universitaria Meyer Istituto di Ricovero e Cura a Carattere Scientifico
Florence, Italy
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Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Brescia, 25123, Italy
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Center for Clinical Research (Nova Scotia Health)
Halifax, Nova Scotia, Canada
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Centre Hospitalier Universitaire de Sherbrooke CHUS
Sherbrooke, Quebec, Canada
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Centro de Alta Especialidad En Reumatologia E Investigacion Del Potosi SC
San Luis Potosí City, Mexico
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Chang Gung Medical Foundation Kaohsiung Chang Gung Memorial Hospital
Kaohsiung City, Taiwan
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Chinese PLA General Hospital
Beijing, Beijing Municipality, China
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Emory Univeristy
Atlanta, Georgia, 30322, United States
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Fujita Health University Hospital
Shinjuku-Ku, Japan
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GI PROS Research - Dedicated Research Facility
Naples, Florida, 34102, United States
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Hacettepe University Faculty of Medicine
Altındağ, Ankara, 06230, Turkey (Türkiye)
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Haut-Lévèque Hospital Usn Building South Hospital Group
Pessac, Bordeaux, 33604, France
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Henry Ford Hospital
Detroit, Michigan, 48202, United States
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Hiroshima University Hospital
Hiroshima, Japan
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Hospital Italiano de Buenos Aires
Buenos Aires, Argentina
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Hospital Universitario Ramón y Cajal
Madrid, Madrid, 28034, Spain
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Hospital Universitario Virgen del Rocio
Seville, Spain
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Hospital de la Santa Creu i Sant Pau
Barcelona, 08025, Spain
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Hospital of University of Occupational and Environmental Health
Kitakyushu, Fukuoka, 807-8555, Japan
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Hôpital Beaujon
Paris, France
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Hôpital de la Pitié Salpétrière
Paris, France
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Hôpitaux Universitaires de Marseille Timone
Saint-Pierre, Marseille, 13005, France
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Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Mexico City, Mexico City, Mexico
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John Radcliffe Hospital
Oxford, United Kingdom
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Kagawa University Hospital
Hiragi, Kagawa-ken, Japan
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Kanazawa Medical University Hospital
Kokura, Fukuoka, Japan
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Kanazawa University Hospital
Kanazawa, Ishikawa-ken, Japan
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Kansai Medical University Hospital
Hirakata, Japan
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Keio University Hospital
Shinjuku-Ku, Tokyo, Japan
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Kita-Harima Medical Center
Ono, Japan
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LMU Klinikum der Universität München
München, Bavaria, Germany
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Linkou Chang Gung Memorial Hospital
Taoyuan, 333, Taiwan
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Marmara University Pendik Training and Research Hospital
Pendik, Istanbul, Turkey (Türkiye)
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Massachusetts General Hospital
Boston, Massachusetts, 02114, United States
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Nagaoka Red Cross Hospital
Nagaoka, Japan
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Nagasaki University Hospital
Nagasaki, Japan
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Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji im. Prof. Dr hab. Med. Eleonory Reicher
Warsaw, Masovian Voivodeship, Poland
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Osaka Metropolitan University Hospital
Osaka, Osaka, Japan
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Ospedale San Giovanni Bosco
Turin, Piedmont, 10128, Italy
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Ospedale San Raffaele S.r.l. - PPDS
Milan, Italy
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Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
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Peking University First Hospital
Beijing, Beijing Municipality, China
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Renji Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China
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Sapporo Medical University Hospital
Sapporo, Japan
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Seoul National University Hospital
Seoul, Seoul, 03080, South Korea
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Shanxi Bethune Hospital
Taiyuan, Shanxi, China
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Shinshu University Hospital
Matsumoto, Nagano, 390-8621, Japan
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St. Marianna University Hospital
Kawasaki, Japan
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Stanford Medicine
Stanford, California, 94305, United States
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Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy
Bydgoszcz, Poland
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Taipei Veterans General Hospital
Taipei, Taiwan
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Tazuke Kofukai Medical Research Institute Kitano Hospital
Osaka, Japan
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The Institute of Medical Science, The University of Tokyo Hospital
Minato-ku, Tokyo, Japan
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The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
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Tokyo Medical Center Hospital
Meguro City, Japan
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Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital
Bunkyō-Ku, Tokyo, Japan
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Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Wuhai, Hubei, China
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Toyama University Hospital
Toyama, Toyama, Japan
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University of Verona
Verona, 37134, Italy
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Universitätsklinikum Ulm
Ulm, Germany
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Vall d'Hebron University Hospital
Barcelona, 08035, Spain
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West China Hospital of Sichuan University
Chengdu, Sichuan, China
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Yantai Yuhuangding Hospital
Yantai, Shandong, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- New drug aims to stop IgG4 disease relapses without Long-Term steroids
- Experimental CAR-T injection aims to tame autoimmune diseases
- Scientists investigate immune cell role in rare IgG4 disease
- Old drug, new hope: could filgotinib tame rare immune diseases?
- New scan could shine a light on hidden inflammation
- New drug shows promise for rare inflammatory disease