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Brain scans probe how obesity may shape memory

NCT ID NCT07796932

Knowledge-focused Sponsor: University Hospital, Bordeaux Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
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Cancelled
Cancelled before anyone took part.

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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

Researchers at Bordeaux University Hospital are studying whether obesity in middle age is linked to memory problems. They plan to enroll 150 adults aged 30 to 50 with a BMI between 30 and 45. Participants will undergo MRI brain scans to measure key brain regions and complete memory and thinking tests. The goal is to see if memory difficulties vary among people with obesity and whether inflammation plays a role.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Magnetic resonance imaging (MRI) and neuropsychological tests (CANTAB) and questionnaires
What this could lead to
If it works, this could clarify how obesity-related inflammation affects memory, pointing toward ways to protect brain health in middle-aged adults with obesity.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The findings may not apply to all people with obesity, and the role of inflammation remains uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Feb 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Recruitment will take place within the Specialised Obesity Centre at Bordeaux University Hospital. As part of their obesity treatment within the department, new patients first attend a consultation, after which they are usually admitted for a five-day educational programme to undergo a comprehensive initial multidisciplinary assessment (covering medical, dietary, psychological, physical activity and social aspects).

Ages

30 to 50 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients suffering from obesity with a BMI between 30 and 45 kg/m² * Patients aged between 30 and 50 receiving educational care during the week at the CSO (Endocrinology, Diabetology and Nutrition Department) of the Bordeaux University Hospital. * Right-handed patients * Persons affiliated with or beneficiaries of a social security scheme. * Free, informed and express consent Exclusion Criteria: * Patients currently undergoing treatment with neuroleptics or who have stopped treatment within the last 3 months. * Pregnant or breastfeeding patients * Known current or past neurological disease * Proven depressive syndrome treated * Patients with type 1 or type 2 diabetes * Uncontrolled dysthyroidism * MMS\< 25 * Patients with proven genetic obesity * Contraindication to MRI * Chronic use of NSAIDs or corticosteroids * Loss of 5% of body weight in the 3 months prior to the study * Acute infection * Persons deprived of their liberty by judicial or administrative decision * Adults subject to legal protection measures (guardianship, curatorship, judicial protection)

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity (disorder)

How to take part

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  1. The official record

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