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Can we unlock muscle growth in obesity?

NCT ID NCT07774676

Knowledge-focused Sponsor: University of Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 19, 2026 · Last updated Aug 20, 2026 · Updated 1 time

Summary

This study investigates why people with overweight or obesity often have a reduced muscle-building response to resistance exercise and protein intake compared to lean individuals. Researchers will compare muscle tissue samples from lean and overweight/obese participants before and after a single-leg exercise session and a protein drink. By examining cellular processes like mTORC1 signaling and autophagy, they hope to identify specific pathways that could be targeted in future treatments to improve muscle metabolism in this population.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Skeletal muscle biopsy and venous blood sampling procedures
What this could lead to
If successful, this could identify specific cellular pathways that, when targeted, might help people with overweight or obesity build muscle more effectively.
What could go wrong
This is an early-stage observational study with a small number of participants, so findings may not apply broadly. The procedures are invasive and carry minor risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2026

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited from around the West Midlands area via recruitment media.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age - 18-45yrs * BMI - 18.5-24.9kg/m2 OR \>28kg/m2 (self-declaration, or calculated by research team based on height and weight) * Weight Stable i.e. no change in weight of more than 5% in previous 6 months * Meeting UK Physical activity guidelines (150 mins moderate or 75 mins vigorous activity/wk) * Not involved in structured exercise training in previous 6 months * No other diagnosed metabolic or neuromuscular conditions (self-declaration) Exclusion Criteria: * Currently using anti-diabetes medication (insulin, metformin, sulphonylureas, meglitinides, thiazolidinediones, DPP- 4 inhibitors, GLP-1 inhibitors). * Currently taking cholesterol lowering medications (statins) * Currently engaged in active weight loss programmes or using weight loss medication * Chronic kidney disease (moderate to severe reduction in kidney function), defined as eGFR \<30 ml/min/1.73m2 identified by self declaration. * Pregnant or breast feeding * Currently using anti-coagulation medication * Hypothyroidism * Type 1 diabetes * Current or recent weakness/injury to either leg that may affect muscle function or ability to exercise * Current gastrointestinal issue/condition that may affect digestion and absorption of protein drink * Individuals who follow a vegan diet or have intolerance/allergies to Whey protein. * Previous adverse reaction to local anaethetic (lidocaine or marcaine).

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Overweight and obese adults

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham

    RECRUITING

    Birmingham, B152TT, United Kingdom

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