Could a single infusion of modified immune cells tame lupus kidney flares?

NCT ID NCT07053800

Recruiting now Disease control Sponsor: Autolus Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This study tests a one-time treatment called Obe-cel, made from a patient's own immune cells, for severe lupus nephritis that hasn't improved with standard care. About 35 people aged 12 to 65 will receive the infusion and be monitored for up to 24 months. The main goal is to see if the treatment can make signs of kidney disease disappear within 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Obe-cel (obecabtagene autoleucel), a CAR T-cell therapy
What this could lead to: If it works, this could point toward a new treatment option for people with severe lupus nephritis who haven't responded to other therapies.
What could go wrong: This is an early Phase 2 trial with only 35 participants, so results may not apply to everyone. CAR T-cell therapy can have serious side effects, and long-term safety is unknown.

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Conditions

The condition(s) this trial relates to.

lupus nephritis systemic lupus erythematosus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUPUS NEPHRITIS

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Addenbrooke's Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom
Bristol Haematology and Oncology Centre
RECRUITING

Bristol, BS1 3LH, United Kingdom

Contact Email: •••••@•••••
Great Ormond Street Hospital
RECRUITING

London, WC1N 3JH, United Kingdom
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States
Instituto D´Or de Pesquisa e Ensino - Hospital São Rafael
RECRUITING

Salvador, Estado de Bahia, 41253-190, Brazil
Manchester Royal Infirmary
RECRUITING

Manchester, M13 9WL, United Kingdom
Queen Elizabeth Hospital Birmingham
RECRUITING

Birmingham, B15 2TH, United Kingdom

Contact Email: •••••@•••••
Queen Elizabeth University Hospital
RECRUITING

Glasgow, G51 4TF, United Kingdom
State University of New York Upstate Medical Center (SUNY)
RECRUITING

Syracuse, New York, 13210, United States
Texas Transplant Institute
RECRUITING

San Antonio, Texas, 78229, United States
University College Hospital
RECRUITING

London, MW1 2PG, United Kingdom
University General Hospital ATTIKON
RECRUITING

Athens, 12461, Greece
University General Hospital of Patras
RECRUITING

Pátrai, 26504, Greece
Western General Hospital Edinburgh
RECRUITING

Edinburgh, EH4 2XU, United Kingdom

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