Experimental therapy aims to reset immune system in lupus patients

NCT ID NCT07053800

Recruiting now Disease control Sponsor: Autolus Limited Source: ClinicalTrials.gov ↗

First seen Apr 28, 2026 · Last updated May 06, 2026 · Updated 1 time

Summary

This study tests a new treatment called obe-cel for people with severe lupus that affects the kidneys and hasn't improved with standard therapies. Obe-cel is designed to destroy harmful immune cells that drive the disease. The trial will enroll 35 people aged 12 to 65 and check if the treatment can make kidney disease disappear for at least 6 months, while also monitoring safety and long-term effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Accurate Clinical Research Inc - Victoria
ACTIVE_NOT_RECRUITING

Houston, Texas, 77034, United States
Addenbrooke's Hospital
RECRUITING

Cambridge, CB2 0QQ, United Kingdom

Contact Email: •••••@•••••
Banner MD Anderson Cancer Center at Canyon Springs
ACTIVE_NOT_RECRUITING

Gilbert, Arizona, 85234, United States
Bristol Haematology and Oncology Centre
ACTIVE_NOT_RECRUITING

Bristol, BS1 3LH, United Kingdom
Centro de Estudos em Terapias Inovadoras
ACTIVE_NOT_RECRUITING

Curitiba, Paraná, 80030-110, Brazil
City of Hope
ACTIVE_NOT_RECRUITING

Duarte, California, 91010, United States
DASA - Hospital Nove de Julho
ACTIVE_NOT_RECRUITING

São Paulo, 01228-200, Brazil
Emory
ACTIVE_NOT_RECRUITING

Atlanta, Georgia, 30322, United States
Great Ormond Street Hospital - PPDS
ACTIVE_NOT_RECRUITING

London, WC1N 3JH, United Kingdom
H Lee Moffitt Cancer Center and Research Institute
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33612, United States
Hospital Alemao Oswaldo Cruz (HAOC)
ACTIVE_NOT_RECRUITING

São Paulo, 01327-001, Brazil
Hospital Sao Rafael
ACTIVE_NOT_RECRUITING

Salvador, Estado de Bahia, 41253, Brazil
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
ACTIVE_NOT_RECRUITING

São Paulo, 05403-000, Brazil
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
ACTIVE_NOT_RECRUITING

São Paulo, 05403-010, Brazil
Manchester Royal Infirmary - PPDS
RECRUITING

Manchester, M13 9WL, United Kingdom

Contact Email: •••••@•••••
Queen Elizabeth Hospital Birmingham
ACTIVE_NOT_RECRUITING

Birmingham, B15 2TH, United Kingdom
Queen Elizabeth University Hospital - PPDS
ACTIVE_NOT_RECRUITING

Glasgow, G51 4TF, United Kingdom
SER - Serviços Especializados em Reumatologia da Bahia S/S - ME
ACTIVE_NOT_RECRUITING

Salvador, Estado de Bahia, 40050, Brazil
Stanford University
ACTIVE_NOT_RECRUITING

Stanford, California, 94305, United States
State University of New York Upstate Medical Center (SUNY)
ACTIVE_NOT_RECRUITING

Syracuse, New York, 13210, United States
Tampa General Hospital
ACTIVE_NOT_RECRUITING

Tampa, Florida, 33606, United States
Texas Childrens Hospital/Baylor
ACTIVE_NOT_RECRUITING

Houston, Texas, 77030, United States
Texas Transplant Institute
ACTIVE_NOT_RECRUITING

San Antonio, Texas, 78229, United States
The Tisch Cancer Institute - 1470 Madison Avenue
ACTIVE_NOT_RECRUITING

New York, New York, 10029, United States
University College Hospital - PPDS
RECRUITING

London, MW1 2PG, United Kingdom

Contact Email: •••••@•••••
Western General Hospital Edinburgh - PPDS
ACTIVE_NOT_RECRUITING

Edinburgh, EH4 2XU, United Kingdom

Conditions

Explore the condition pages connected to this study.

LUPUS NEPHRITIS