New eye drops could replace reading glasses for millions
NCT ID NCT05646719
First seen Jun 24, 2026 · Last updated Jul 14, 2026 · Updated 3 times
Summary
This Phase 3 trial tested Nyxol eye drops, alone or with low-dose pilocarpine, in 333 adults aged 40–64 with presbyopia (age-related difficulty seeing up close). The goal was to improve near vision without losing distance vision. Participants received drops and were measured after 30 minutes. If effective, this could offer a non-surgical alternative to reading glasses.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Phentolamine ophthalmic solution 0.75% (Nyxol) and low-dose pilocarpine hydrochloride ophthalmic solution 0.4%
- What this could lead to
- If successful, this could provide a simple eye drop treatment to help people with presbyopia see up close without reading glasses.
- What could go wrong
- This is a completed Phase 3 trial, but results are not yet published. Eye drops may cause side effects like eye irritation or blurred distance vision, and the benefit may be modest or temporary.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Athens, OH
Athens, Ohio, 45701, United States
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Austin, TX
Austin, Texas, 73301, United States
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Azusa, CA
Azusa, California, 91702, United States
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Bloomington, MN
Bloomington, Minnesota, 55420, United States
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Chesterfield, MO
Chesterfield, Missouri, 63017, United States
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Cranberry Township, PA
Cranberry Township, Pennsylvania, 16066, United States
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Delray Beach, FL
Delray Beach, Florida, 33484, United States
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Fargo, ND
Fargo, North Dakota, 58103, United States
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Garner, NC
Garner, North Carolina, 27529, United States
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Houston, TX
Houston, Texas, 77055, United States
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Kansas City, MO
Kansas City, Missouri, 64133, United States
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Lake Villa, IL
Lake Villa, Illinois, 60046, United States
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Longwood, FL
Longwood, Florida, 32779, United States
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Memphis, TN
Memphis, Tennessee, 38119, United States
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New Freedom, PA
New Freedom, Pennsylvania, 17349, United States
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Newport Beach, CA
Newport Beach, California, 92663, United States
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Northridge, CA
Northridge, California, 91325, United States
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Phoenix, AZ
Phoenix, Arizona, 85003, United States
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Pittsburg, KS
Pittsburg, Kansas, 66762, United States
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Rochester, NY
Rochester, New York, 14618, United States
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Roswell, GA
Roswell, Georgia, 30076, United States
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Saint Louis, MO
St Louis, Missouri, 63128, United States
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San Antonio, TX
San Antonio, Texas, 78229, United States
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Shawnee Mission, KS
Shawnee Mission, Kansas, 66204, United States
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Sioux Falls, SD
Sioux Falls, South Dakota, 57108, United States
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Smithtown, NY
Smithtown, New York, 11787, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a new contact lens sharpen both near and far vision for aging eyes?
- A tiny corneal pocket may restore Close-Up vision — no glasses needed
- Laser eye surgery may offer a One-Time fix for reading glasses — a trial puts it to the test
- Eye drops may offer a new way to read without glasses — a trial puts them to the test
- Tiny corneal lens holds up after 4 years for near vision
- Could a micro implant replace reading glasses?