New hope for Tough-to-Treat blood cancers: NX-5948 trial opens

NCT ID NCT07221500

Recruiting now Disease control Sponsor: Nurix Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 02, 2026 · Updated 1 time

Summary

This study tests an experimental drug called NX-5948 in adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) that has come back or not responded to prior treatments, including BTK and BCL-2 inhibitors. The main goal is to see if the drug can shrink or control the cancer. About 100 participants will take the drug, and the study lasts up to 5 years or longer if the disease stays under control.

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Conditions

The condition(s) this trial relates to.

B-cell chronic lymphocytic leukemia lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) SMALL LYMPHOCYTIC LYMPHOMA (SLL)

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

AUSL della Romagna UO Ematologia
RECRUITING

Ravenna, 48121, Italy
Aidport Sp. z o.o.
RECRUITING

Skorzewo, 60-185, Poland
Azienda Ospedaliero-Universitaria di Alessandria SS. Antonio e Biagio e Cesare Arrigo
RECRUITING

Alessandria, 15121, Italy
CHU de Nantes
RECRUITING

Nantes, 44000, France
City of Hope
RECRUITING

Duarte, California, 91010, United States
Colorado Blood Institute
RECRUITING

Denver, Colorado, 80218, United States
Duke University
RECRUITING

Durham, North Carolina, 27705, United States
Florida Cancer Specialists
RECRUITING

Sarasota, Florida, 34232, United States
Fort Wayne Oncology and Hematology
RECRUITING

Fort Wayne, Indiana, 46804, United States
Hematology Oncology of Indiana
RECRUITING

Indianapolis, Indiana, 46260, United States
IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola
RECRUITING

Bologna, 40138, Italy
Karmanos Cancer Center
RECRUITING

Detroit, Michigan, 48201, United States
Maryland Oncology Hematology
RECRUITING

Silver Spring, Maryland, 20904, United States
Novant Health Cancer Institute
RECRUITING

Winston-Salem, North Carolina, 27103, United States
Oncology & Hematology Associates of Southwest VA
RECRUITING

Norfolk, Virginia, 23502, United States
Oncology Hematology Care
RECRUITING

Fairfield, Ohio, 45014, United States
Ospedale San Raffaele S.r.l.
RECRUITING

Milan, 20132, Italy
Oxford University Hospitals NHS Foundation Trust
RECRUITING

Headington, Oxford, OX3 9D, United Kingdom
Pratia Hematologia Sp. z o.o.
RECRUITING

Katowice, 40-519, Poland
Pratia S.A.
RECRUITING

Krakow, 30-225, Poland
Pratia Warszawa / Pratia MTZ
RECRUITING

Warsaw, 02-172, Poland
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Texas Oncology - Center South
RECRUITING

Austin, Texas, 78705, United States
The Christie NHS Foundation Trust
RECRUITING

Manchester, M20 4BX, United Kingdom
The Royal Marsden NHS Foundation Trust
RECRUITING

London, SW3 6JJ, United Kingdom
UPMC Hillman Cancer Center
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of Cincinnati
RECRUITING

Cincinnati, Ohio, 45221, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Miami
RECRUITING

Coral Gables, Florida, 33146, United States
University of Utah
RECRUITING

Salt Lake City, Utah, 84112, United States
Virginia Cancer Specialists, PC
RECRUITING

Fairfax, Virginia, 22031, United States
Virginia Oncology Associates
RECRUITING

Norfolk, Virginia, 23502, United States

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