Blood test may take guesswork out of lung nodule decisions

NCT ID NCT04171492

First seen Sep 30, 2025 · Last updated May 15, 2026 · Updated 34 times

Summary

This study looks at whether a blood test called Nodify XL2 can help doctors better manage lung nodules that have a low to moderate chance of being cancer. About 2,000 adults over 40 with a solid lung nodule between 8 and 30 mm are taking part. The goal is to see if the test results lead to more accurate diagnoses and fewer unnecessary procedures.

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Contacts and locations

Locations

  • Beth Israel Deaconess

    Boston, Connecticut, 02215, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Duke University

    Durham, North Carolina, 27705, United States

  • Indiana University

    Indianapolis, Indiana, 46202, United States

  • Massachusetts General Hospital

    Boston, Connecticut, 02114, United States

  • Mayo Clinic

    Rochester, Minnesota, 55905, United States

  • McGill University Health Centre

    Montreal, Quebec, H3H 2R9, Canada

  • MedStar

    Washington D.C., District of Columbia, 20010, United States

  • Medical University of South Carolina

    Charleston, South Carolina, 29425, United States

  • Mount Sinai Health System

    New York, New York, 10029, United States

  • Northwell Health

    New York, New York, 11042, United States

  • Prisma Health

    Greenville, South Carolina, 29605, United States

  • Ralph H Johnson VA Medical Center

    Charleston, South Carolina, 29401, United States

  • Southeastern Research Center

    Winston-Salem, North Carolina, 27103, United States

  • The Johns Hopkins University

    Baltimore, Maryland, 21205, United States

  • The Ohio State University

    Coulmbus, Ohio, 43210, United States

  • The Oregon Clinic

    Portland, Oregon, 97220, United States

  • The University of North Carolina

    Chapel Hill, North Carolina, 27599, United States

  • The Washington University

    St Louis, Missouri, 63110, United States

  • University of Calgary

    Calgary, Alberta, T2W 1S7, Canada

  • University of Colorado

    Aurora, Colorado, 80045, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

  • University of Texas Medical Branch

    Galveston, Texas, 77555, United States

  • University of Texas Southwestern

    Dallas, Texas, 75390, United States

  • Virginia Commonwealth University

    Richmond, Virginia, 23219, United States

Conditions

Explore the condition pages connected to this study.