New blood test could spare thousands from unnecessary lung surgery

NCT ID NCT04171492

Ongoing Diagnosis Sponsor: Biodesix, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing whether a blood test called Nodify XL2 can help doctors decide how to manage lung nodules that have a low to moderate chance of being cancer. About 2,000 adults with solid lung nodules between 8 and 30 mm are taking part. The goal is to see if using the test leads to better decisions, such as avoiding unnecessary biopsies or surgeries for harmless nodules.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Nodify XL2 proteomic classifier (blood test)

What this could lead to

If successful, this test could help doctors decide which lung nodules need further testing or surgery, avoiding unnecessary invasive procedures for benign nodules.

What could go wrong

This is a large trial but results are not yet available. The test may not improve patient outcomes enough to change standard practice, and false results could still lead to missed cancers or unnecessary procedures.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

non-small cell lung carcinoma pulmonary coin lesion

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NODULE SOLITARY PULMONARY NON-SMALL CELL CARCINOMA

Contacts and locations

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Locations

Beth Israel Deaconess

Boston, Connecticut, 02215, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Duke University

Durham, North Carolina, 27705, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Massachusetts General Hospital

Boston, Connecticut, 02114, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
McGill University Health Centre

Montreal, Quebec, H3H 2R9, Canada
MedStar

Washington D.C., District of Columbia, 20010, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Mount Sinai Health System

New York, New York, 10029, United States
Northwell Health

New York, New York, 11042, United States
Prisma Health

Greenville, South Carolina, 29605, United States
Ralph H Johnson VA Medical Center

Charleston, South Carolina, 29401, United States
Southeastern Research Center

Winston-Salem, North Carolina, 27103, United States
The Johns Hopkins University

Baltimore, Maryland, 21205, United States
The Ohio State University

Coulmbus, Ohio, 43210, United States
The Oregon Clinic

Portland, Oregon, 97220, United States
The University of North Carolina

Chapel Hill, North Carolina, 27599, United States
The Washington University

St Louis, Missouri, 63110, United States
University of Calgary

Calgary, Alberta, T2W 1S7, Canada
University of Colorado

Aurora, Colorado, 80045, United States
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Texas Medical Branch

Galveston, Texas, 77555, United States
University of Texas Southwestern

Dallas, Texas, 75390, United States
Virginia Commonwealth University

Richmond, Virginia, 23219, United States