Immune cells injected into brain tumors: a new hope for kids?

NCT ID NCT05887882

Terminated Disease control Sponsor: Sabine Mueller, MD, PhD Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early-phase trial tests whether natural killer (NK) cells from healthy donors can be safely injected into the brain tumors of children and young adults whose cancer has returned or is growing. The NK cells are specially treated to resist the tumor's defenses. The main goals are to find the safest dose and check for side effects. The study is currently on hold.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: natural killer cells from healthy donors
What this could lead to: If it works, this could point toward a new treatment option for children and young adults with hard-to-treat brain tumors.
What could go wrong: This is a very early phase I trial with only 24 participants, so safety and dosing are still being figured out. It is currently suspended, and there is no guarantee it will lead to an effective treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

childhood neoplasm neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PEDIATRIC BRAIN TUMOR PEDIATRIC NEOPLASM RECURRENT PEDIATRIC BRAIN TUMOR

Contacts and locations

Locations

Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Indiana University

Indianapolis, Indiana, 46202, United States
Johns Hopkins

Baltimore, Maryland, 21287, United States
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Seattle Children's

Seattle, Washington, 98105, United States
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
University of Alabama Birmingham

Birmingham, Alabama, 35294, United States
University of California, San Francisco

San Francisco, California, 94143, United States
Washington University in Saint Louis

St Louis, Missouri, 63130, United States

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