Immunotherapy combo before Chemo-Radiation shows promise in esophageal cancer trial

NCT ID NCT03044613

First seen Apr 09, 2026 · Last updated Apr 28, 2026 · Updated 3 times

Summary

This early-phase trial tests whether giving immunotherapy drugs (nivolumab alone or with relatlimab) before standard chemoradiation is safe and feasible for people with operable stage II/III esophageal or gastroesophageal junction cancer. The study involves 32 participants and aims to see if this approach can improve outcomes by changing the tumor's environment. The main goal is to check for side effects and ensure treatment doesn't delay surgery.

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Contacts and locations

Locations

  • Alleghany Health Network

    Pittsburgh, Pennsylvania, 15212, United States

  • Baylor University/ Charles A. Sammons Cancer Center

    Dallas, Texas, 75246, United States

  • Johns Hopkins University

    Baltimore, Maryland, 21287, United States

Conditions

Explore the condition pages connected to this study.