Immunotherapy duo shows promise for Tough-to-Treat kidney cancer
NCT ID NCT03075423
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tested whether combining two immunotherapy drugs, nivolumab and ipilimumab, works better than standard treatments for people with advanced non-clear cell kidney cancer. About 316 participants received either the drug combo or standard therapy. The main goal was to see how many were alive after 12 months. This study aims to find better options for a rare and hard-to-treat cancer type.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nivolumab plus ipilimumab (immunotherapy drugs)
- What this could lead to
- If successful, this combination could become a new first-line treatment option for people with advanced non-clear cell kidney cancer, potentially improving survival.
- What could go wrong
- This is a phase 2 trial, so results are still preliminary. The combination may not prove better than standard care and can cause immune-related side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre François Baclesse
Caen, France
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Centre Hospitalier Départemental de Vendée
La Roche-sur-Yon, France
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Centre Hospitalier Universitaire de Bordeaux
Bordeaux, France
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Centre Leon Berard
Lyon, France
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Charite Berlin (Campus Virchow-Klinikum)
Berlin, Germany
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Gent University Hospital (Universitair Ziekenhuis Gent)
Ghent, Belgium
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Goethe University Frankfurt
Frankfurt am Main, D-60590, Germany
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Heine University
Düsseldorf, Germany
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Hospita de la Santa Creu i Sant Pau
Barcelona, Spain
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Hospital Clinic de Barcelona
Barcelona, Spain
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Hospital Univeritario 12 de Octubre
Madrid, Spain
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Hospital Vall d'Hebron
Barcelona, Spain
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Institut Gustave Roussy
Paris, France
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Klinik für Urologie, Universitätsklinik
Jena, Germany
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Klinikum Rechts der Isar der TU München
München, Germany
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Les Hoptaux Universitaires de Strasbourg
Strasbourg, France
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Medizinische Hochschule Hannover
Hanover, Lower Saxony, 30625, Germany
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Nationales Zentrum für Tumorerkrankungen (NCT)
Heidelberg, 69120, Germany
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Netherlands Cancer Institute
Amsterdam, Netherlands
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Royal Free London NHS Foundation Trust
London, United Kingdom
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The Christie NHS Foundation Trust
Manchester, United Kingdom
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Thomayer Hospital
Prague, Czechia
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University Hospital
Homburg/Saar, Germany
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University Hospital Erlangen
Erlangen, 91054, Germany
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University Hospital Greifswald
Greifswald, Germany
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University Hospital Hradec Králové
Hradec Králové, Czechia
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University Medical Center Groningen
Groningen, Netherlands
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University of Muenster
Münster, 48149, Germany
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Universitätsklinik Tübingen
Tübingen, Germany
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Universitätsklinikum Essen
Essen, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a pill boost the immune system to fight Hard-to-Treat cancers?
- Old drug, new hope: mercaptopurine tested against rare cancer syndrome
- Radiation boosts immunotherapy in kidney cancer trial
- Immunotherapy duo shows promise in kidney cancer battle
- Brain cancer trial halted early: can Memory-Sparing radiation help when tumors return?
- Folic acid may soothe cancer treatment side effects