Goethe University

This phase 2 trial is testing whether adding the drug isatuximab to standard chemotherapy can help adults with T-cell acute lymphoblastic leukemia (T-ALL) that has relapsed or not responded to treatment. The study enrolls 40 people in two groups: one for those with a full relapse…

This study tests whether a type of brain stimulation called cTBS can reduce cravings for alcohol in people with alcohol addiction. 34 adults will receive 15 stimulation sessions over 5 days, and researchers will measure changes in their cravings, heart rate, and brain activity. T…

This study tests whether urolithin A, a dietary supplement, can improve the immune system's response to standard immunotherapy drugs in people with newly diagnosed solid tumors like lung cancer or melanoma. 45 participants will be randomly assigned to receive either urolithin A o…

This study tests a new type of talk therapy called Process Based Therapy (PBT) for people with depression or anxiety. Instead of a one-size-fits-all plan, PBT uses daily mood check-ins from a smartphone app to help therapists tailor treatment to each person's changing needs. The …

This study observes 100 people with depression who are already receiving transcranial magnetic stimulation (TMS) therapy. Researchers use brain scans and symptom questionnaires to see how brain networks change during treatment and whether these changes can predict who gets better…

This study is a large registry that will collect medical information and biological samples from up to 10,000 adults with acute lymphoblastic leukemia (ALL) and related blood cancers. The goal is to track how patients are diagnosed, treated, and how they fare over time. By gather…

This study is observing 60 people who will have their bladder removed (cystectomy) using a robot-assisted technique. Researchers want to measure how much blood is lost during surgery, how much pain patients feel afterward, and how many need blood transfusions. The goal is to gath…