New drug tested to protect fertility in women with rare tumors
NCT ID NCT07176689
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests the drug nirogacestat in 50 premenopausal women with desmoid tumors (a type of non-cancerous but aggressive growth). The main goal is to see if the drug affects ovarian function, such as menstrual periods and hormone levels. Participants take nirogacestat orally, and researchers monitor for any temporary or lasting changes in fertility.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
nirogacestat (oral tablet)
What this could lead to
If successful, this study could show that nirogacestat is safe for ovarian function, allowing younger women with desmoid tumors to preserve fertility while controlling their disease.
What could go wrong
This is a small, early-phase study with no placebo group, so results may not apply broadly. The drug may still cause ovarian toxicity or other side effects.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DESMOID TUMOR are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Academisch Ziekenhuis Leiden
RECRUITINGLeiden, 2333 ZA, Netherlands
Contact Email: •••••@•••••
-
Cambridge University Hospitals NHS Foundation Trust
RECRUITINGCambridge, CB2 0QQ, United Kingdom
Contact Email: •••••@•••••
-
Cliniques Universitaires Saint-Luc (CUSL)
RECRUITINGBrussels, 1200, Belgium
Contact Email: •••••@•••••
-
Fondazione IRCCS Istituto Nazionale dei Tumori Milano
RECRUITINGMilan, 20133, Italy
Contact Email: •••••@•••••
-
Hospital Fundacion Jimenez Diaz
RECRUITINGMadrid, 28040, Spain
Contact Email: •••••@•••••
-
Hospital General Universitario Gregorio Maranon
RECRUITINGMadrid, 28007, Spain
Contact Email: •••••@•••••
-
Hospital Universitari i Politecnic La Fe de Valencia
RECRUITINGValencia, 46026, Spain
Contact Email: •••••@•••••
-
Hospital Universitario 12 de Octubre
RECRUITINGMadrid, 28041, Spain
Contact Email: •••••@•••••
-
Hospital Universitario La Paz
RECRUITINGMadrid, 28046, Spain
Contact Email: •••••@•••••
-
Hospital Universitario Miguel Servet
RECRUITINGZaragoza, 50009, Spain
Contact Email: •••••@•••••
-
Hospital de la Santa Creu i Sant Pau
RECRUITINGBarcelona, 08041, Spain
Contact Email: •••••@•••••
-
IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant Orsola
RECRUITINGBologna, 40138, Italy
Contact Email: •••••@•••••
-
IRCCS Istituto Ortopedico Rizzoli di Bologna
RECRUITINGBologna, 40138, Italy
Contact Email: •••••@•••••
-
IRCCS Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l.
RECRUITINGMeldola, Forli-Cesena, 47014, Italy
Contact Email: •••••@•••••
-
Institut Catala d'Oncologia
RECRUITINGBarcelona, 08907, Spain
Contact Email: •••••@•••••
-
Istituto Nazionale Tumori I.R.C.C.S- Fondazione G. Pascale
RECRUITINGNaples, 80131, Italy
Contact Email: •••••@•••••
-
La Fondazione e l'Istituto di Candiolo
RECRUITINGCandiolo, Torino, 10060, Italy
Contact Email: •••••@•••••
-
Nederlands Kanker Instituut - Antoni van Leeuwenhoek Ziekenhuis (NKI-AVL)
RECRUITINGAmsterdam, 1066 CX, Netherlands
Contact Email: •••••@•••••
-
Policlinico Universitario Campus Bio-Medico
RECRUITINGRoma, 00128, Italy
Contact Email: •••••@•••••
-
The Christie NHS Foundation Trust
RECRUITINGManchester, M20 4BX, United Kingdom
Contact Email: •••••@•••••
-
The Royal Marsden NHS Foundation Trust
RECRUITINGLondon, SW3 6JJ, United Kingdom
Contact Email: •••••@•••••
-
Universitaetsmedizin Mannheim
RECRUITINGMannheim, 68167, Germany
Contact Email: •••••@•••••
-
University College London Hospitals NHS Foundation Trust
RECRUITINGLondon, NW1 2PG, United Kingdom
Contact Email: •••••@•••••