Triple-threat treatment aims to make inoperable lung cancer removable
NCT ID NCT07309952
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase II trial tests whether giving a short course of radiation, followed by two cycles of immunotherapy (sintilimab) plus chemotherapy, can shrink advanced lung cancer that has spread to lymph nodes on the opposite side of the chest. The goal is to make the cancer operable and improve long-term outcomes. The study enrolls 28 adults aged 18–75 with previously untreated stage IIIB or IIIC non-small cell lung cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sintilimab (immunotherapy), paclitaxel or nab-paclitaxel (chemotherapy), and stereotactic body radiotherapy (radiation)
- What this could lead to
- If successful, this approach could help shrink tumors enough to allow surgery in patients with advanced lung cancer, potentially improving survival and reducing recurrence.
- What could go wrong
- This is a small, early-phase trial with only 28 participants, so results may not apply to everyone. The combination of radiation, immunotherapy, and chemotherapy can cause significant side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Sun Yat-sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
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