First test of new precision drug targets Cancer's genetic weakness
NCT ID NCT06239467
Summary
This is the first study in people for a new drug called OKI-219, designed to target a specific genetic mutation (PI3KαH1047R) found in some advanced cancers. The main goals are to find a safe dose and see how the body handles the drug, both alone and combined with other cancer treatments. The study will enroll about 200 adults with advanced solid tumors, including breast cancer, who have this specific mutation and have run out of standard treatment options.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Asan Medical Center
RECRUITINGSeoul, 05505, South Korea
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California Cancer Associates for Research and Excellence
RECRUITINGEncinitas, California, 92024, United States
Contact Email: •••••@•••••
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Centre Antoine Lacassagne
RECRUITINGNice, 06189, France
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Centre Leon Berard
RECRUITINGLyon, 69008, France
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Centre Oscar Lambret
RECRUITINGLille, 59020, France
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Centre de Lutte Contre le Cancer CLCC - Centre Georges Francois Leclerc (CGFL)
RECRUITINGDijon, 21079, France
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Comprehensive Cancer Centers of Nevada
RECRUITINGLas Vegas, Nevada, 89169, United States
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Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
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GZA Hopsitals Campus Sint-Augustinus
RECRUITINGWilrijk, 2610, Belgium
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Gachon University Gil Medical Center
RECRUITINGIncheon, 21565, South Korea
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Hoag - Huntington Beach
RECRUITINGNewport Beach, California, 92663, United States
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Hopital Lyon Sud
RECRUITINGPierre-Bénite, 69310, France
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Hospital Beata Maria Ana
RECRUITINGMadrid, 28007, Spain
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Hospital Universitario 12 de Octubre
RECRUITINGMadrid, 28041, Spain
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Institut Gustave Roussy
RECRUITINGVillejuif, 94805, France
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Institut Jules Bordet
RECRUITINGAnderlecht, 1070, Belgium
Contact Email: •••••@•••••
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Istituto Clinico Humanitas
RECRUITINGRozzano, 20089, Italy
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Karmanos Cancer Insitute
WITHDRAWNDetroit, Michigan, 48201, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Email: •••••@•••••
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NEXT Oncology Phase I Unit / IOB- Hospital Quironsalud Barcelona
RECRUITINGBarcelona, 08023, Spain
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NEXT Oncology Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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Ospedale San Gerardo-ASST Monza
RECRUITINGMonza, 20900, Italy
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Ospedale San Raffaele
RECRUITINGMilan, 20132, Italy
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Regents of the University of Colorado
RECRUITINGAurora, Colorado, 80045, United States
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SCRI Oncology Partners - Nashville
RECRUITINGNashville, Tennessee, 37203, United States
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START - Madrid
RECRUITINGMadrid, 28050, Spain
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Samsung Medical Center
RECRUITINGSeoul, 06351, South Korea
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Sarah Cannon Research Institute at HealthONE
RECRUITINGDenver, Colorado, 80218, United States
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Seoul National University Hospital
RECRUITINGSeoul, 03080, South Korea
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Severance Hospital
RECRUITINGSeoul, 03722, South Korea
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Stony Brook University
RECRUITINGStony Brook, New York, 11794, United States
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UCLA Jonsson Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90024, United States
Contact Email: •••••@•••••
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UZ Leuven - Campus Gasthuisberg
RECRUITINGLeuven, 3000, Belgium
Contact Email: •••••@•••••
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University of California San Diego UCSD
RECRUITINGLa Jolla, California, 92093, United States
Contact Email: •••••@•••••
Conditions
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