New hope for advanced breast cancer patients after standard treatments fail

NCT ID NCT06016738

Recruiting now Disease control Sponsor: Olema Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

Summary

This trial is testing whether a new oral medication called OP-1250 works better than current standard hormone therapies for people with advanced breast cancer that has continued to grow despite previous hormone treatments. The study will enroll about 510 adults whose cancer is hormone-receptor positive and HER2-negative, and who have already tried a specific combination therapy. Researchers will compare how long patients live without their cancer getting worse on the new drug versus standard options.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

Clinical Trial Site
RECRUITING

Tucson, Arizona, 85719, United States
Clinical Trial Site
NOT_YET_RECRUITING

Fountain Valley, California, 92708, United States
Clinical Trial Site
NOT_YET_RECRUITING

Glendale, California, 91204, United States
Clinical Trial Site
COMPLETED

La Jolla, California, 92093, United States
Clinical Trial Site
RECRUITING

Los Alamitos, California, 90720, United States
Clinical Trial Site
RECRUITING

Los Angeles, California, 90027, United States
Clinical Trial Site
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Whittier, California, 90602, United States
Clinical Trial Site
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Aurora, Colorado, 80045, United States
Clinical Trial Site
RECRUITING

Denver, Colorado, 80218, United States
Clinical Trial Site
RECRUITING

Golden, Colorado, 80401, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Grand Junction, Colorado, 81505, United States
Clinical Trial Site
RECRUITING

Danbury, Connecticut, 06810, United States
Clinical Trial Site
RECRUITING

Newark, Delaware, 19713, United States
Clinical Trial Site
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Margate, Florida, 33063, United States
Clinical Trial Site
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Orlando, Florida, 32804, United States
Clinical Trial Site
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Plantation, Florida, 33324, United States
Clinical Trial Site
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Tamarac, Florida, 33321, United States
Clinical Trial Site
RECRUITING

Atlanta, Georgia, 30322, United States
Clinical Trial Site
RECRUITING

Chicago, Illinois, 60616-2315, United States
Clinical Trial Site
RECRUITING

Chicago, Illinois, 60637, United States
Clinical Trial Site
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Urbana, Illinois, 61801, United States
Clinical Trial Site
WITHDRAWN

Baton Rouge, Louisiana, 70809, United States
Clinical Trial Site
RECRUITING

New Orleans, Louisiana, 70112, United States
Clinical Trial Site
RECRUITING

Baltimore, Maryland, 21201, United States
Clinical Trial Site
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Boston, Massachusetts, 02111, United States
Clinical Trial Site
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Detroit, Michigan, 48202, United States
Clinical Trial Site
RECRUITING

Saint Louis Park, Minnesota, 55426, United States
Clinical Trial Site
RECRUITING

Woodbury, Minnesota, 55125, United States
Clinical Trial Site
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Lincoln, Nebraska, 68516, United States
Clinical Trial Site
RECRUITING

Farmington, New Mexico, 87401, United States
Clinical Trial Site
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New York, New York, 10032, United States
Clinical Trial Site
WITHDRAWN

Port Jefferson Station, New York, 11776, United States
Clinical Trial Site
RECRUITING

Dayton, Ohio, 45415, United States
Clinical Trial Site
WITHDRAWN

Toledo, Ohio, 43623, United States
Clinical Trial Site
RECRUITING

Portland, Oregon, 97239, United States
Clinical Trial Site
RECRUITING

Sayre, Pennsylvania, 18840, United States
Clinical Trial Site
RECRUITING

Nashville, Tennessee, 37203, United States
Clinical Trial Site
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Nashville, Tennessee, 37208, United States
Clinical Trial Site
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Nashville, Tennessee, 37232, United States
Clinical Trial Site
RECRUITING

Dallas, Texas, 75246, United States
Clinical Trial Site
RECRUITING

Dallas, Texas, 75390, United States
Clinical Trial Site
RECRUITING

Houston, Texas, 77054, United States
Clinical Trial Site
RECRUITING

Webster, Texas, 77598, United States
Clinical Trial Site
RECRUITING

Ogden, Utah, 84405, United States
Clinical Trial Site
WITHDRAWN

Spokane, Washington, 99204, United States
Clinical Trial Site
RECRUITING

Spokane, Washington, 99208, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Bahía Blanca, Buenos Aires, B8000HXM, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Mar del Plata, Buenos Aires, B7600FZN, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Mar del Plata, Buenos Aires, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Córdoba, Córdoba Province, X5000HHW, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Córdoba, Córdoba Province, X5008HHW, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

San Salvador de Jujuy, Jujuy Province, 4600, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

La Rioja, La Rioja Province, 5300, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Viedma, Río Negro Province, R8500ACE, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Rosario, Santa Fe Province, S2013DTC, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Rosario, Santa Fe Province, S2013KDS, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

San Miguel de Tucumán, Tucumán Province, 4000, Argentina
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Buenos Aires, C14626ABP, Argentina
Clinical Trial Site
RECRUITING

Gosford, New South Wales, 2250, Australia
Clinical Trial Site
RECRUITING

Westmead, New South Wales, 2145, Australia
Clinical Trial Site
RECRUITING

Adelaide, South Australia, 5000, Australia
Clinical Trial Site
RECRUITING

Ballarat Central, Victoria, 3355, Australia
Clinical Trial Site
RECRUITING

Clayton, Victoria, 3168, Australia
Clinical Trial Site
RECRUITING

Shepparton, Victoria, 3630, Australia
Clinical Trial Site
RECRUITING

Nedlands, Western Australia, 6009, Australia
Clinical Trial Site
RECRUITING

Wels, 4600, Austria
Clinical Trial Site
RECRUITING

Wiener Neustadt, 2700, Austria
Clinical Trial Site
RECRUITING

Edegem, Antwerpen, 2650, Belgium
Clinical Trial Site
RECRUITING

Wilrijk, Antwerpen, 2610, Belgium
Clinical Trial Site
RECRUITING

Woluwe-Saint-Lambert, Brussels Capital, 1200, Belgium
Clinical Trial Site
RECRUITING

Charleroi, Hainaut, 6060, Belgium
Clinical Trial Site
WITHDRAWN

Leuven, Vlaams Brabant, Belgium
Clinical Trial Site
RECRUITING

Salvador, Estado de Bahia, 41253-190, Brazil
Clinical Trial Site
RECRUITING

Brasília, Federal District, 70.390-140, Brazil
Clinical Trial Site
RECRUITING

São Luís, Maranhão, 65.060-645, Brazil
Clinical Trial Site
RECRUITING

Belo Horizonte, Minas Gerais, 30150-221, Brazil
Clinical Trial Site
RECRUITING

Curitiba, Paraná, 81520-060, Brazil
Clinical Trial Site
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Recife, Pernambuco, 50070-480, Brazil
Clinical Trial Site
RECRUITING

Porto Alegre, Rio Grande do Sul, 90035-903, Brazil
Clinical Trial Site
RECRUITING

Porto Alegre, Rio Grande do Sul, 90050-170, Brazil
Clinical Trial Site
RECRUITING

Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
Clinical Trial Site
RECRUITING

Itajaí, Santa Catarina, 88301-220, Brazil
Clinical Trial Site
RECRUITING

Jaú, São Paulo, 17210-080, Brazil
Clinical Trial Site
RECRUITING

Sorocaba, São Paulo, 18052-775, Brazil
Clinical Trial Site
NOT_YET_RECRUITING

Porto Alegre, 90470-340, Brazil
Clinical Trial Site
RECRUITING

Rio de Janeiro, 22281-100, Brazil
Clinical Trial Site
RECRUITING

Panagyurishte, Pazardzhik, 4500, Bulgaria
Clinical Trial Site
RECRUITING

Sofia, Sofia-Grad, 1407, Bulgaria
Clinical Trial Site
WITHDRAWN

Vratsa, Vratsa, 3000, Bulgaria
Clinical Trial Site
RECRUITING

Calgary, Alberta, T2N 5G2, Canada
Clinical Trial Site
RECRUITING

London, Ontario, N6A 5W9, Canada
Clinical Trial Site
RECRUITING

Toronto, Ontario, M5G 1X5, Canada
Clinical Trial Site
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Clinical Trial Site
WITHDRAWN

Hradec Králové, Královéhradecký kraj, 500 12, Czechia
Clinical Trial Site
RECRUITING

Nový Jičín, Moravskoslezský kraj, 741 01, Czechia
Clinical Trial Site
RECRUITING

Olomouc, Olomoucký kraj, 779 00, Czechia
Clinical Trial Site
RECRUITING

Brno, 625 00, Czechia
Clinical Trial Site
RECRUITING

Prague, 140 59, Czechia
Clinical Trial Site
RECRUITING

Bourg-en-Bresse, Ain, 01000, France
Clinical Trial Site
RECRUITING

Besançon, Doubs, 25030, France
Clinical Trial Site
RECRUITING

Nantes, Loire-Atlantique, 44277, France
Clinical Trial Site
RECRUITING

Nantes, Loire-Atlantique, 44805, France
Clinical Trial Site
RECRUITING

Compiègne, Oise, 60200, France
Clinical Trial Site
RECRUITING

Clermont-Ferrand, Puy-de-Dôme, 63011, France
Clinical Trial Site
RECRUITING

Le Mans, Sarthe, 7200, France
Clinical Trial Site
RECRUITING

Villejuif, Val-de-Marne, 94805, France
Clinical Trial Site
RECRUITING

Caen, 14000, France
Clinical Trial Site
RECRUITING

Montpellier, 34070, France
Clinical Trial Site
NOT_YET_RECRUITING

Paris, 75014, France
Clinical Trial Site
RECRUITING

Karlsruhe, Baden-Wurttemberg, 76135, Germany
Clinical Trial Site
RECRUITING

Krefeld, North Rhine-Westphalia, 47805, Germany
Clinical Trial Site
RECRUITING

Velbert, North Rhine-Westphalia, 42551, Germany
Clinical Trial Site
RECRUITING

Dresden, Saxony, 01307, Germany
Clinical Trial Site
RECRUITING

Kiel, Schleswig-Holstein, 24105, Germany
Clinical Trial Site
WITHDRAWN

Central, Hong Kong, 100176, Hong Kong
Clinical Trial Site
RECRUITING

Hong Kong, Hong Kong, 999077, Hong Kong
Clinical Trial Site
RECRUITING

Kowloon, Hong Kong, 999077, Hong Kong
Clinical Trial Site
RECRUITING

Hong Kong, 999077, Hong Kong
Clinical Trial Site
RECRUITING

Pécs, Baranya, 7624, Hungary
Clinical Trial Site
RECRUITING

Kecskemét, Bács-Kiskun county, 6000, Hungary
Clinical Trial Site
RECRUITING

Debrecen, Hajdú-Bihar, 4032, Hungary
Clinical Trial Site
RECRUITING

Avellino, Campania, 83100, Italy
Clinical Trial Site
RECRUITING

Bologna, Emilia-Romagna, 40138, Italy
Clinical Trial Site
RECRUITING

Meldola, Emilia-Romagna, 47014, Italy
Clinical Trial Site
RECRUITING

Modena, Emilia-Romagna, 41124, Italy
Clinical Trial Site
RECRUITING

Reggio Emilia, Emilia-Romagna, 42100, Italy
Clinical Trial Site
WITHDRAWN

Udine, Friuli Venezia Giulia, 33100, Italy
Clinical Trial Site
RECRUITING

Rome, Lazio, 00144, Italy
Clinical Trial Site
RECRUITING

Rome, Lazio, 00168, Italy
Clinical Trial Site
RECRUITING

Milan, Lombardy, 20141, Italy
Clinical Trial Site
RECRUITING

Rozzano, Lombardy, 20089, Italy
Clinical Trial Site
NOT_YET_RECRUITING

Piacenza, Piacenza, 29121, Italy
Clinical Trial Site
RECRUITING

Alessandria, Piedmont, 15121, Italy
Clinical Trial Site
RECRUITING

Aviano, Pordenone, 33081, Italy
Clinical Trial Site
NOT_YET_RECRUITING

Ancona, 60126, Italy
Clinical Trial Site
RECRUITING

Genova, 16132, Italy
Clinical Trial Site
NOT_YET_RECRUITING

Naples, 80131, Italy
Clinical Trial Site
RECRUITING

Padua, 35128, Italy
Clinical Trial Site
RECRUITING

Pavia, 27100, Italy
Clinical Trial Site
RECRUITING

Kota Bharu, Kelantan, 16150, Malaysia
Clinical Trial Site
RECRUITING

Ipoh, Perak, 30450, Malaysia
Clinical Trial Site
RECRUITING

George Town, Pulau Pinang, 10450, Malaysia
Clinical Trial Site
RECRUITING

Putrajaya, Putramya, 62250, Malaysia
Clinical Trial Site
RECRUITING

Kuching, Sarawak, 93586, Malaysia
Clinical Trial Site
RECRUITING

Petaling Jaya, Selangor, 46050, Malaysia
Clinical Trial Site
RECRUITING

Kuala Lumpur, WP, 59100, Malaysia
Clinical Trial Site
RECRUITING

Guadalajara, Jalisco, 44670, Mexico
Clinical Trial Site
NOT_YET_RECRUITING

Mexico City, Mexico City, 06760, Mexico
Clinical Trial Site
WITHDRAWN

Puebla City, Puebla, 72530, Mexico
Clinical Trial Site
RECRUITING

San Luis Potosí City, San Luis Potosí, 78209, Mexico
Clinical Trial Site
RECRUITING

Monterrey, 64460, Mexico
Clinical Trial Site
RECRUITING

Oaxaca City, 68020, Mexico
Clinical Trial Site
RECRUITING

Sinaloa, 80020, Mexico
Clinical Trial Site
RECRUITING

Amsterdam, North Holland, 1081 HV, Netherlands
Clinical Trial Site
RECRUITING

Rotterdam, South Holland, 3083 AN, Netherlands
Clinical Trial Site
RECRUITING

Lublin, Lublin Voivodeship, 20-090, Poland
Clinical Trial Site
RECRUITING

Lodz, Lódzkie, 93-513, Poland
Clinical Trial Site
RECRUITING

Otwock, Masovian Voivodeship, 05-400, Poland
Clinical Trial Site
RECRUITING

Brzozów, Podkarpackie Voivodeship, 36-200, Poland
Clinical Trial Site
RECRUITING

Rzeszów, Podkarpackie Voivodeship, 35-021, Poland
Clinical Trial Site
RECRUITING

Gdynia, Pomeranian Voivodeship, 81-519, Poland
Clinical Trial Site
NOT_YET_RECRUITING

Gdansk, 80-214, Poland
Clinical Trial Site
RECRUITING

Krakow, 31-115, Poland
Clinical Trial Site
RECRUITING

Krakow, 31-501, Poland
Clinical Trial Site
RECRUITING

Poznan, 60-192, Poland
Clinical Trial Site
WITHDRAWN

Wroclaw, 50-450, Poland
Clinical Trial Site
RECRUITING

Coimbra, Coimbra District, 3000-075, Portugal
Clinical Trial Site
RECRUITING

Lisbon, Lisbon District, 1099-023, Portugal
Clinical Trial Site
RECRUITING

Lisbon, Lisbon District, 1500-458, Portugal
Clinical Trial Site
RECRUITING

Porto, Porto District, 4200-072, Portugal
Clinical Trial Site
RECRUITING

Senhora da Hora, Porto District, 4464-513, Portugal
Clinical Trial Site
RECRUITING

Mayagüez, Puerto Rico, 00682-6391, Puerto Rico
Clinical Trial Site
RECRUITING

Oradea, Bihor County, 410469, Romania
Clinical Trial Site
RECRUITING

Brasov, Brașov County, 500152, Romania
Clinical Trial Site
RECRUITING

Bucharest, București, 014146, Romania
Clinical Trial Site
RECRUITING

Cluj-Napoca, Cluj, 400015, Romania
Clinical Trial Site
NOT_YET_RECRUITING

Cluj-Napoca, Cluj, 400132, Romania
Clinical Trial Site
RECRUITING

Craiova, Dolj, 200542, Romania
Clinical Trial Site
RECRUITING

Iași, Iaşi, 700106, Romania
Clinical Trial Site
RECRUITING

Timișoara, Timiș County, 300239, Romania
Clinical Trial Site
NOT_YET_RECRUITING

Bucharest, 030171, Romania
Clinical Trial Site
NOT_YET_RECRUITING

Iași, 700451, Romania
Clinical Trial Site
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
Clinical Trial Site
RECRUITING

Busan, 49201, South Korea
Clinical Trial Site
RECRUITING

Seoul, 02841, South Korea
Clinical Trial Site
RECRUITING

Seoul, 03080, South Korea
Clinical Trial Site
RECRUITING

Seoul, 03722, South Korea
Clinical Trial Site
RECRUITING

Seoul, 05505, South Korea
Clinical Trial Site
RECRUITING

Seoul, 06273, South Korea
Clinical Trial Site
RECRUITING

Seoul, 06591, South Korea
Clinical Trial Site
RECRUITING

Seoul, 08308, South Korea
Clinical Trial Site
RECRUITING

Suwon, 16499, South Korea
Clinical Trial Site
RECRUITING

Badajoz, Badajoz, 06080, Spain
Clinical Trial Site
NOT_YET_RECRUITING

Badalona, Barcelona, 08916, Spain
Clinical Trial Site
NOT_YET_RECRUITING

Manresa, Barcelona, 08243, Spain
Clinical Trial Site
RECRUITING

Girona, Girona, 17007, Spain
Clinical Trial Site
RECRUITING

León, León, 24071, Spain
Clinical Trial Site
RECRUITING

Lleida, Lleida, 25198, Spain
Clinical Trial Site
RECRUITING

Madrid, Madrid, 28050, Spain
Clinical Trial Site
RECRUITING

Pamplona, Navarre, 31008, Spain
Clinical Trial Site
RECRUITING

Seville, Sevilla, 41009, Spain
Clinical Trial Site
NOT_YET_RECRUITING

Reus, Tarragona, 43204, Spain
Clinical Trial Site
RECRUITING

Valencia, Valencia, 46010, Spain
Clinical Trial Site
RECRUITING

Alicante, 03010, Spain
Clinical Trial Site
NOT_YET_RECRUITING

Barcelona, 08023, Spain
Clinical Trial Site
RECRUITING

Fuenlabrada, 28942, Spain
Clinical Trial Site
RECRUITING

Madrid, 28033, Spain
Clinical Trial Site
NOT_YET_RECRUITING

Murcia, 30120, Spain
Clinical Trial Site
RECRUITING

Santiago de Compostela, 15706, Spain
Clinical Trial Site
RECRUITING

Changhua, 500, Taiwan
Clinical Trial Site
RECRUITING

Kaohsiung City, 80756, Taiwan
Clinical Trial Site
RECRUITING

Taichung, 40447, Taiwan
Clinical Trial Site
RECRUITING

Taichung, 433, Taiwan
Clinical Trial Site
RECRUITING

Tainan, 736, Taiwan
Clinical Trial Site
RECRUITING

Taipei, 100, Taiwan
Clinical Trial Site
RECRUITING

Taipei, 111, Taiwan
Clinical Trial Site
RECRUITING

Taipei, 11217, Taiwan
Clinical Trial Site
RECRUITING

Taipei, 114, Taiwan
Clinical Trial Site
RECRUITING

Bangkok, 10300, Thailand
Clinical Trial Site
RECRUITING

Bangkok, 10330, Thailand
Clinical Trial Site
RECRUITING

Bangkok, 10700, Thailand
Clinical Trial Site
RECRUITING

Chiang Mai, 50180, Thailand
Clinical Trial Site
RECRUITING

Samut Sakhon, 74120, Thailand
Clinical Trial Site
RECRUITING

Songkhla, 90110, Thailand
Clinical Trial Site
RECRUITING

Leicester, Leicestershire, LE1 5WW, United Kingdom
Clinical Trial Site
RECRUITING

Nottingham, Nottingham, NG5 1PB, United Kingdom
Clinical Trial Site
RECRUITING

Taunton, Somerset, TA1 5DA, United Kingdom
Clinical Trial Site
RECRUITING

Bodelwyddan, LL18 5UJ, United Kingdom
Clinical Trial Site
RECRUITING

London, EC1A 7BE, United Kingdom
Clinical Trial site
RECRUITING

Santa Cruz de Tenerife, 38320, Spain
Clinical Trials Site
WITHDRAWN

Jacksonville, Florida, 32223, United States
Clinical Trials Site
RECRUITING

Hong Kong, 999077, Hong Kong
Clinical Trials Site
RECRUITING

Sungai Petani, Kedah, 8000, Malaysia

Conditions

Explore the condition pages connected to this study.

ADVANCED BREAST CANCER BREAST CANCER ER POSITIVE BREAST CANCER HER2 NEGATIVE BREAST CARCINOMA METASTATIC BREAST CANCER