Glow-in-the-Dark dye could help surgeons avoid nerve damage
NCT ID NCT06227585
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed trial tested a dye called bevonescein (ALM-488) and a special imaging system (REVEAL 475) to make nerves glow during head and neck surgery. 155 patients received the dye before surgery, and surgeons used the system to see nerves more clearly. The goal was to help surgeons avoid accidentally damaging nerves, which can cause problems like facial weakness or voice changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Bevonescein (ALM-488) dye
What this could lead to
If successful, this could help surgeons avoid accidentally cutting nerves during head and neck surgery, potentially reducing complications like facial paralysis or voice changes.
What could go wrong
This is an early combined Phase 2/3 trial with 155 participants, so results may not apply to all surgeries. The dye and device may not improve nerve visibility enough to change surgical outcomes.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Alume Biosciences
La Jolla, California, 92037, United States