Glow-in-the-Dark dye could help surgeons avoid nerve damage
NCT ID NCT06227585
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed trial tested a dye called bevonescein (ALM-488) and a special imaging system (REVEAL 475) to make nerves glow during head and neck surgery. 155 patients received the dye before surgery, and surgeons used the system to see nerves more clearly. The goal was to help surgeons avoid accidentally damaging nerves, which can cause problems like facial weakness or voice changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Bevonescein (ALM-488) dye
- What this could lead to
- If successful, this could help surgeons avoid accidentally cutting nerves during head and neck surgery, potentially reducing complications like facial paralysis or voice changes.
- What could go wrong
- This is an early combined Phase 2/3 trial with 155 participants, so results may not apply to all surgeries. The dye and device may not improve nerve visibility enough to change surgical outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Alume Biosciences
La Jolla, California, 92037, United States
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