New combo therapy aims to save more breasts in High-Risk cancer
NCT ID NCT02806258
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding a short course of focused radiation to standard chemotherapy before surgery could improve outcomes for women with aggressive breast cancers. The trial enrolled 362 patients with luminal B or triple-negative breast cancer that was too large for initial breast-conserving surgery. Participants received either chemotherapy alone or chemotherapy plus accelerated partial breast irradiation, followed by surgery. The study was terminated early, so the full impact on complete response rates and breast conservation remains uncertain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
chemotherapy (anthracycline and/or taxane based) and accelerated partial breast irradiation
What this could lead to
If successful, this approach could increase the chance of a complete response and allow more women to have breast-conserving surgery instead of mastectomy.
What could go wrong
The trial was terminated early, so results are limited. Adding radiation before surgery may increase side effects without clear benefit.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AP-HP Henri mondor
Paris, France
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CHI Créteil
Créteil, France
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CHU Avicenne
Paris, France
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CHU de Grenoble
Grenoble, 38043, France
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H. Hartmann Institute of Radiotherapy and Radiosurgery
Paris, France
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Tenon hospital
Paris, France