New combo therapy aims to save more breasts in High-Risk cancer
NCT ID NCT02806258
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding a short course of focused radiation to standard chemotherapy before surgery could improve outcomes for women with aggressive breast cancers. The trial enrolled 362 patients with luminal B or triple-negative breast cancer that was too large for initial breast-conserving surgery. Participants received either chemotherapy alone or chemotherapy plus accelerated partial breast irradiation, followed by surgery. The study was terminated early, so the full impact on complete response rates and breast conservation remains uncertain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- chemotherapy (anthracycline and/or taxane based) and accelerated partial breast irradiation
- What this could lead to
- If successful, this approach could increase the chance of a complete response and allow more women to have breast-conserving surgery instead of mastectomy.
- What could go wrong
- The trial was terminated early, so results are limited. Adding radiation before surgery may increase side effects without clear benefit.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AP-HP Henri mondor
Paris, France
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CHI Créteil
Créteil, France
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CHU Avicenne
Paris, France
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CHU de Grenoble
Grenoble, 38043, France
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H. Hartmann Institute of Radiotherapy and Radiosurgery
Paris, France
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Tenon hospital
Paris, France
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