New Shot-in-Tumor combo aims to beat melanoma before surgery

NCT ID NCT07230613

Recruiting now Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This phase 2 trial tests injecting two immunotherapy drugs (ipilimumab and nivolumab) directly into melanoma tumors before surgical removal. The goal is to shrink or eliminate the cancer while reducing the severe side effects that can occur when these drugs are given through a vein. About 50 adults with stage III melanoma that can be surgically removed will receive up to three injections over three weeks, then have surgery. Researchers will check if the tumor is gone or mostly gone after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ipilimumab and nivolumab (immunotherapy drugs)
What this could lead to: If successful, this approach could offer a safer, more effective way to shrink melanoma tumors before surgery, potentially reducing recurrence and avoiding harsh side effects.
What could go wrong: This is a small, early-phase trial (50 participants) testing a new injection method. The treatment may not work as hoped, could cause unexpected side effects, or delay surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for CUTANEOUS MELANOMA, STAGE III are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cutaneous melanoma melanoma mucosal melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CUTANEOUS MELANOMA, STAGE III MUCOSAL MELANOMA

Contacts and locations

Locations

AP-HM Marseille (Hôpital de la Timone)
RECRUITING

Marseille, 13005, France
AP-HP- Hôpital Saint-Louis
RECRUITING

Paris, 75010, France
CHU de Bordeaux- Hôpital Saint-André
RECRUITING

Bordeaux, 33075, France
Centre Léon Bérard
RECRUITING

Lyon, 69373, France
Gustave Roussy
RECRUITING

Villejuif, 94805, France
Hospices Civils de Lyon (Hôpital Lyon Sud)
RECRUITING

Lyon, 69495, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.