New pill shows promise for sickle cell sufferers

NCT ID NCT05405114

Completed Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This study tested a new oral medicine called NDec in 96 adults with sickle cell disease. The goal was to see if it safely raises hemoglobin levels and reduces painful crises. Participants took capsules twice weekly for about a year, with some also continuing their usual hydroxyurea. Results will show if NDec offers a new way to control this lifelong condition.

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Conditions

The condition(s) this trial relates to.

sickle cell disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SICKLE CELL DISEASE

Contacts and locations

Locations

Abdali Hospital

Amman, Jordan
Acıbadem Adana Hastanesi-Hematoloji

Adana, 01130, Turkey (Türkiye)
Aflac Cancer/Blood Dis CCH

Atlanta, Georgia, 30342, United States
Aghia Sophia Childrens' Hospital

Goudi, 11527, Greece
All India Institute of Medical Sciences (AIIMS), Raipur

Raipur, Chhattisgarh, 492099, India
Ap-Hp-Hopital Europeen Georges Pompidou

Paris, 75015, France
Ap-Hp-Hopital Henri Mondor

Créteil, 94000, France
Atrium Levine Children's/Atrium Health

Charlotte, North Carolina, 28204, United States
Augusta University

Augusta, Georgia, 30912, United States
Azienda Ospedale Universita Padova

Padova, 35128, Italy
Azienda Ospedaliera Universitaria Integrata Verona Policlinico GB Rossi - Borgo Roma

Verona, 37134, Italy
BAPS Pramukh Swami Hospital

Surat, Gujarat, 395009, India
Baylor College of Medicine Texas Childen's Hospital

Houston, Texas, 77030, United States
Baylor College of Medicine_Houston

Houston, Texas, 77030, United States
Carole&Ray Neag Comp S.C. Ctr

Farmington, Connecticut, 06030, United States
Center for Inherited Blood Dis

Orange, California, 92868, United States
Central Middlesex Hospital

London, NW10 7NS, United Kingdom
Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-3

Grenoble, 38043, France
Charlotte Maxeke Johannesburg Academic Hospital

Parktown, Johannesburg, Gauteng, 2193, South Africa
Children's Hospitals And Clinics Of Minnesota

Minneapolis, Minnesota, 55404, United States
Christian Medical College Hospital, Vellore

Ranipet, Tamil Nadu, 632517, India
Christian Medical College Hospital, Vellore

Vellore, Tamil Nadu, 632004, India
Clinical and Transl Res Center

Aurora, Colorado, 80045, United States
Cure 4 the Kids Foundation

Las Vegas, Nevada, 89135, United States
Dan L. Duncan Comprehensive Cancer Center

Houston, Texas, 77030, United States
Dayton Children's Hosptial

Dayton, Ohio, 45404, United States
Duke Comprehen Sickle Cell

Durham, North Carolina, 27710, United States
East Carolina Univ-Greenville

Greenville, North Carolina, 27834-4300, United States
East Carolina Univ-Greenville

Greenville, North Carolina, 27834, United States
Emory University School Of Med

Atlanta, Georgia, 30333, United States
Emory University School Of Med

Atlanta, Georgia, 30342, United States
Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Foundation for Sickle Cell Disease Research

Hollywood, Florida, 33023, United States
Gauhati Medical College and Hospital

Guwahati, Assam, 781032, India
Gen Univ Hospital of Patras, Thalassemia/Hemoglobinopathies

Pátrai, 26504, Greece
General Hospital Of Larissa Koutlibaneio And Triantafylleio - Thalassemia and SCD Unit

Larissa, 41221, Greece
Government Medical College and Hospital

Nagpur, Maharashtra, 440003, India
Government Medical College and Super Speciality Hospital, Nagpur

Nagpur, Maharashtra, 440003, India
Government Medical College and Super Speciality Hospital, Nagpur

Nagpur, Maharashtra, 440009, India
Government Medical College, Kozhikode

Kozhikode, Kerala, 673008, India
Guy's Hospital

London, SE1 9RT, United Kingdom
Hacettepe Üniversitesi Hastanesi- Hematoloji

Ankara, 06230, Turkey (Türkiye)
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Harbor-UCLA Medical Center

Torrance, California, 90502-2004, United States
Hemophilia Center of Western PA

Pittsburgh, Pennsylvania, 15213, United States
Hospices Civils de Lyon-Hopital Edouard Herriot

Lyon, 69437, France
Hospital Nini

Tripoli, 1434, Lebanon
Hospital Regional Universitario de Málaga

Málaga, 29010, Spain
Hospital Universitario La Paz

Madrid, 28046, Spain
Hospitalier de l'Universite de Montreal (CHUM)-Hôpital Notre

Montreal, Quebec, H2L 4M1, Canada
Howard University

Washington D.C., District of Columbia, 20060, United States
Howard University Hospital Department Med

Washington D.C., District of Columbia, 20060, United States
IMS and SUM Hospital

Bhubaneswar, Odisha, 751003, India
Interfaith Medical Center

Brooklyn, New York, 11238, United States
Irbid Specialty Hospital Clinical Research Center

Irbid, Jordan
Istiklal Hospital

Amman, Jordan
J.S.S.Hospital

Mysore, Karnataka, 570004, India
Jacobi Medical Center

The Bronx, New York, 10461, United States
K.J Somaiya Hospital and Research Centre

Mumbai, Maharashtra, 400022, India
KIMS - Kingsway Hospital

Nagpur, 440001, India
Keck Medical Center of USC - Outpatient Clinic

Los Angeles, California, 90033, United States
King Abdullah University Hospital

Irbid, Jordan
King's College Hospital

London, SE5 9RS, United Kingdom
LHSC - Victoria Hospital

London, Ontario, N6A 5W9, Canada
LHSC - Victoria Hospital

London, Ontario, ON N6A 5W9, Canada
Manchester Royal Infirmary

Manchester, M13 9WL, United Kingdom
Mass General Cancer Center

Boston, Massachusetts, 02114, United States
McGill University Health Centre

Montreal, Quebec, H4A 3J1, Canada
Medical College of Wisconsin & Zablocki VAMC

Milwaukee, Wisconsin, 53226, United States
Medical Univ of SC Charleston

Charleston, South Carolina, 29425, United States
Mersin Üniversitesi Tip Fakültesi Hastanesi- Çiftlikköy Yerleşkesi- Hematoloji

Mersin, 33110, Turkey (Türkiye)
Mississippi Center Advanced Medicine

Madison, Mississippi, 39110, United States
Montefiore Medical Center

The Bronx, New York, 10467, United States
Mount Sinai School of Medicine

New York, New York, 10029, United States
NRS Medical College & Hospital

Kolkata, West Bengal, 700014, India
NRS Medical College & Hospital

Kolkata, West Bengal, 70014, India
Nirmal Hospital Pvt. Ltd.

Surat, Gujarat, 395002, India
Ospedali Galliera

Genova, 16128, Italy
Penn Comprehensive Hemophilia & Thrombosis Program

Philadelphia, Pennsylvania, 19104, United States
Policlinico GB Rossi

Verona, 37134, Italy
Queens Hospital Center

Jamaica, New York, 11432-1121, United States
Royal London Hospital_London

London, E1 1BB, United Kingdom
Rush University Med. Cntr

Chicago, Illinois, 60612, United States
S.C.B. Medical College

Cuttack, Odisha, 753007, India
SSG Hospital, Baroda

Vadodara, Gujarat, 390001, India
SSG Hospital, Baroda

Vadodara, Gujarat, 390006, India
Sanjay Gandhi Postgraduate Institute of Medical Sciences

Lucknow, Uttar Pradesh, 226014, India
St Christopher Hosp for Child

Philadelphia, Pennsylvania, 19134, United States
Sultan Qaboos University Hospital

Muscat, Sultanet of Oman/Muscat/Al Khoud, 123, Oman
The Hospital for Sick Children

Toronto, Ontario, M5G 1X8, Canada
The Specialty Hospital, Advanced Clinical Center

Amman, Jordan
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
Toronto General Hospital, Liver Clinic

Toronto, Ontario, M5G 2C4, Canada
Toronto General Hospital, Liver Clinic

Toronto, Ontario, M5G2C4, Canada
Tova Community Health Inc

Wilmington, Delaware, 19805, United States
Tulane Sickle Cell Ctr- So LA

Metairie, Louisiana, 70002, United States
UCSF Oakland Benioff ChildHosp

Oakland, California, 94609, United States
Univ Oklahoma HSC_Okla City

Oklahoma City, Oklahoma, 73104, United States
Univ Texas HSC-Houston

Houston, Texas, 77030, United States
Univ of Alberta Hosp Edmonton

Edmonton, Alberta, T6G 2B7, Canada
Univ of NE Med Center_Omaha

Omaha, Nebraska, 68198, United States
Univer Of Illinois at Chicago

Chicago, Illinois, 60612, United States
University College Hospital - Paediatric Services

London, NW1 2PG, United Kingdom
University Hospital of Wales

Cardiff, CF14 4XW, United Kingdom
University Of South Alabama

Mobile, Alabama, 36617, United States
University Of Tennessee

Memphis, Tennessee, 38163, United States
University Of Virginia Hospital

Charlottesville, Virginia, 22908, United States
University of Florida, College of Medicine Jacksonville

Jacksonville, Florida, 32209, United States
University of Miami Hospital & Clinics

Miami, Florida, 33136, United States
University of Minnesota_Minneapolis_0

Minneapolis, Minnesota, 55455, United States
University of North Carlolina-Chapel Hill

Chapel Hill, North Carolina, 27599, United States
University of Oklahoma Health Sciences Center_Oklahoma City

Oklahoma City, Oklahoma, 73104, United States
Universitätsspital Zürich - Klinik für Medizinische Onkologie und Hämatologie

Zurich, 8091, Switzerland
Victoria Hospital (Bangalore Medical College and Research Institute)

Bangalore, Karnataka, 560002, India
Wayne State University/University Health Center

Detroit, Michigan, 48201, United States
Yashoda hospital

Hyderabad, Telangana, 500082, India
Zydus Medical College & Hospital

Dohad, Gujarat, 389151, India
Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi- Hematoloji

Adana, 01130, Turkey (Türkiye)

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