New pill shows promise for sickle cell sufferers
NCT ID NCT05405114
First seen Nov 01, 2025 · Last updated May 01, 2026 · Updated 26 times
Summary
This study tested a new oral medicine called NDec in 96 adults with sickle cell disease. The goal was to see if it safely raises hemoglobin levels and reduces painful crises. Participants took capsules twice a week for about a year, and some also took hydroxyurea. Results will show if NDec can help control the disease.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Acıbadem Adana Hastanesi-Hematoloji
Adana, 01130, Turkey (Türkiye)
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Aghia Sophia Childrens' Hospital
Goudi, 11527, Greece
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All India Institute of Medical Sciences (AIIMS), Raipur
Raipur, Chhattisgarh, 492099, India
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Azienda Ospedale Universita Padova
Padova, 35128, Italy
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Azienda Ospedaliera Universitaria Integrata Verona Policlinico GB Rossi - Borgo Roma
Verona, 37134, Italy
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BAPS Pramukh Swami Hospital
Surat, Gujarat, 395009, India
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Center for Inherited Blood Dis
Orange, California, 92868, United States
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Central Middlesex Hospital
London, NW10 7NS, United Kingdom
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Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-3
Grenoble, 38043, France
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Charlotte Maxeke Johannesburg Academic Hospital
Parktown, Johannesburg, Gauteng, 2193, South Africa
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Christian Medical College Hospital, Vellore
Ranipet, Tamil Nadu, 632517, India
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Christian Medical College Hospital, Vellore
Vellore, Tamil Nadu, 632004, India
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Clinical and Transl Res Center
Aurora, Colorado, 80045, United States
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Cure 4 the Kids Foundation
Las Vegas, Nevada, 89135, United States
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East Carolina Univ-Greenville
Greenville, North Carolina, 27834, United States
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Fondazione IRCSS Ca' Granda Ospedale Maggiore Policlinico
Milan, 20122, Italy
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Foundation for Sickle Cell Disease Research
Hollywood, Florida, 33023, United States
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Gen Univ Hospital of Patras, Thalassemia/Hemoglobinopathies
Pátrai, 26504, Greece
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General Hospital Of Larissa Koutlibaneio And Triantafylleio - Thalassemia and SCD Unit
Larissa, 41221, Greece
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Government Medical College and Hospital
Nagpur, Maharashtra, 440003, India
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Government Medical College and Super Speciality Hospital, Nagpur
Nagpur, Maharashtra, 440003, India
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Government Medical College and Super Speciality Hospital, Nagpur
Nagpur, Maharashtra, 440009, India
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Government Medical College, Kozhikode
Kozhikode, Kerala, 673008, India
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Guy's Hosptial
London, SE1 9RT, United Kingdom
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Hacettepe Üniversitesi Hastanesi- Hematoloji
Ankara, 06230, Turkey (Türkiye)
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Harbor-UCLA Medical Center
Torrance, California, 90502-2004, United States
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Hospices Civils de Lyon-Hopital Edouard Herriot
Lyon, 69437, France
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Hospital Nini
Tripoli, 1434, Lebanon
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Hospital Regional Universitario de Málaga
Málaga, 29010, Spain
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Hospital Universitario La Paz
Madrid, 28046, Spain
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Howard University
Washington D.C., District of Columbia, 20060, United States
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IMS and SUM Hospital
Bhubaneswar, Odisha, 751003, India
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J.S.S.Hospital
Mysore, Karnataka, 570004, India
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Jacobi Medical Center
The Bronx, New York, 10461, United States
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K.J Somaiya Hospital and Research Centre
Mumbai, Maharashtra, 400022, India
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KIMS - Kingsway Hospital
Nagpur, 440001, India
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Kings College Hospital
London, SE5 9RS, United Kingdom
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LHSC - Victoria Hospital
London, Ontario, ON N6A 5W9, Canada
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Manchester Royal Infirmary
Manchester, M13 9WL, United Kingdom
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McGill University Health Centre
Montreal, Quebec, H4A 3J1, Canada
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Medical Univ of SC Charleston
Charleston, South Carolina, 29425, United States
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Mersin Üniversitesi Tip Fakültesi Hastanesi- Çiftlikköy Yerleşkesi- Hematoloji
Mersin, 33110, Turkey (Türkiye)
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Mississippi Center Advanced Medicine
Madison, Mississippi, 39110, United States
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Mount Sinai School of Medicine
New York, New York, 10029, United States
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NRS Medical College & Hospital
Kolkata, West Bengal, 700014, India
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NRS Medical College & Hospital
Kolkata, West Bengal, 70014, India
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Nirmal Hospital Pvt. Ltd.
Surat, Gujarat, 395002, India
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Ospedali Galliera
Genova, 16128, Italy
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Policlinico GB Rossi
Verona, 37134, Italy
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S.C.B. Medical College
Cuttack, Odisha, 753007, India
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SSG Hospital, Baroda
Vadodara, Gujarat, 390001, India
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SSG Hospital, Baroda
Vadodara, Gujarat, 390006, India
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Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, 226014, India
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St Christopher Hosp for Child
Philadelphia, Pennsylvania, 19134, United States
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Sultan Qaboos University Hospital
Muscat, 123, Oman
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Toronto General Hospital, Liver Clinic
Toronto, Ontario, M5G 2C4, Canada
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Toronto General Hospital, Liver Clinic
Toronto, Ontario, M5G2C4, Canada
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Tulane Sickle Cell Ctr- So LA
Metairie, Louisiana, 70002, United States
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UCSF Oakland Benioff Children's Hospital
Oakland, California, 94609, United States
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Univ Oklahoma HSC_Okla City
Oklahoma City, Oklahoma, 73104, United States
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Univ Texas HSC-Houston
Houston, Texas, 77030, United States
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University Hospital of Wales
Cardiff, CF14 4XW, United Kingdom
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University Of Illinois at Chicago
Chicago, Illinois, 60612, United States
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University Of South Alabama
Mobile, Alabama, 36617, United States
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University of Miami Hospital & Clinics
Miami, Florida, 33136, United States
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University of Oklahoma Health Sciences Center_Oklahoma City
Oklahoma City, Oklahoma, 73104, United States
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Victoria Hospital (Bangalore Medical College and Research Institute)
Bangalore, Karnataka, 560002, India
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Yashoda hospital
Hyderabad, Telangana, 500082, India
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Çukurova Üniversitesi Tıp Fakültesi Balcalı Hastanesi- Hematoloji
Adana, 01130, Turkey (Türkiye)
Conditions
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