New IV drug NAV-240 aims to calm painful skin bumps in hidradenitis suppurativa

NCT ID NCT07384975

Recruiting now Disease control Sponsor: Navigator Medicines, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This study tests whether NAV-240, given as an IV infusion, works better than a placebo for adults with moderate-to-severe hidradenitis suppurativa (HS). HS causes painful, inflamed bumps and tunnels under the skin. The main goal is to see if NAV-240 can reduce these bumps by at least 75% after 16 weeks. About 150 participants will receive either NAV-240 or placebo and be monitored for 22 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NAV-240 (given as an intravenous infusion)
What this could lead to: If successful, this could point toward a new treatment option that reduces painful skin bumps and draining tunnels in people with hidradenitis suppurativa.
What could go wrong: This is an early Phase 2a study with only 150 participants, so results may not apply to everyone. The drug may not work better than placebo, and side effects are still being evaluated.

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Conditions

The condition(s) this trial relates to.

hidradenitis suppurativa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIDRADENITIS SUPPURATIVA (HS)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Accel Research Sites Network
RECRUITING

Maitland, Florida, 32751, United States
Ambulatory for Specialized Medical Help - skin and venereal diseases
RECRUITING

Sofia, Bulgaria
BAG Dres. med. Quist PartG
RECRUITING

Mainz, Germany
Beth Israel Deaconess Medical Center
RECRUITING

Boston, Massachusetts, 02215, United States
Centre de Recherche Saint-Louis (Quebec)
RECRUITING

Montreal, Quebec, QC H1Y 3L1, Canada
Centrum Columbus
RECRUITING

Wroclaw, Poland
Cordova Research Institute
RECRUITING

Miami, Florida, 33182, United States
Debreceni Egyetem Klinikai Központ - Dermatology
RECRUITING

Debrecen, Hungary
Dermedic Jacek Zdybski
RECRUITING

Kielce, Poland
Diagnostic Consultative Center Fokus-5 Medical Establishment for Outpatient Care EOOD
RECRUITING

Sofia, Bulgaria
Equity Medical, LLC
RECRUITING

The Bronx, New York, 10455, United States
FACET Dermatology
RECRUITING

Toronto, Ontario, M4E 1R7, Canada
FWD Clinical Research
RECRUITING

Tamarac, Florida, 33321, United States
Floridian Research Institute
RECRUITING

Miami, Florida, 33179, United States
ForCare Clinical Research
RECRUITING

Tampa, Florida, 33613, United States
Futuremeds Romania - Brasov - Dermatology
RECRUITING

Brasov, Romania
Futuremeds Romania - Galati - Dermatology
RECRUITING

Galati, Romania
Holsamed
RECRUITING

Katowice, Poland
J. W. Goethe Universitaet Frankfurt Zentrum f. Dermatologie
RECRUITING

Frankfurt, Germany
Kentucky Advanced Medical Research LLC
RECRUITING

Murray, Kentucky, 42071, United States
Klinika Ambroziak Dermatologia
RECRUITING

Warsaw, Poland
LTD Aversi Clinic - Dermatology
RECRUITING

Tbilisi, Georgia
LTD Israel-Georgian Medical Research Clinic Healthycore
RECRUITING

Tbilisi, Georgia
LTD MediClub Georgia
RECRUITING

Tbilisi, Georgia
LTD Multiprofile Clinic Consilium Medulla
NOT_YET_RECRUITING

Tbilisi, Georgia
Labderm Essence
RECRUITING

Ossy, Poland
MC Medconsult Pleven
RECRUITING

Pleven, Bulgaria
Medical Center Medconsult Pleven
RECRUITING

Lovech, Bulgaria
Medical Dermatology Specialist
RECRUITING

Phoenix, Arizona, 85006, United States
MplusM - D&H Tamarac Research Center
RECRUITING

Tamarac, Florida, 33321, United States
OT CO Zdrowie
RECRUITING

Warsaw, Poland
Pécsi Tudományegyetem Klinikai Központ - Bőr-, Nemikórtani és Onkoderma
RECRUITING

Pécs, Hungary
Research Toronto
RECRUITING

Toronto, Ontario, M4W 2N2, Canada
SKY Integrative Medical Center
RECRUITING

Ridgeland, Mississippi, 39157, United States
Scottsdale Clinical Trials
RECRUITING

Scottsdale, Arizona, 85260, United States
Spitalul Clinic Colentina - Dermatology II
RECRUITING

Bucharest, Romania
St. Josef Hospital Bochum - Dermatologie, Venerologie und Allergologie
RECRUITING

Bochum, Germany
StracSkin, PLLC
RECRUITING

Portsmouth, New Hampshire, 03801, United States
Universitaetsklinikum Schleswig-Holstein (UKSH) - Campus Kiel - Klinik fuer Dermatologie, Venerologie und Allergologie
RECRUITING

Kiel, Germany
Universitaetsklinikum Schleswig-Holstein (UKSH) - Campus Luebeck
RECRUITING

Lübeck, Germany
Ziaderm Research, LLC
RECRUITING

North Miami Beach, Florida, 33162, United States

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