Fibroid surgery Follow-Up drug trial pulled before it began

NCT ID NCT05538689

Terminated Disease control Sponsor: University of Chicago Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study aimed to see if taking Myfembree (a combination pill) daily after fibroid removal surgery could delay the return of fibroids and improve quality of life. It was designed for premenopausal women with uterine fibroids who had surgery. However, the trial was withdrawn before any participants were enrolled, so no data were collected.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Myfembree (relugolix, estradiol, norethindrone acetate)
What this could lead to: If it had worked, this could point toward a way to delay fibroid regrowth and reduce the need for repeat surgery after myomectomy.
What could go wrong: The trial was withdrawn before enrolling anyone, so no results are available. Even if conducted, it was a small early-phase study, and benefits may not have been confirmed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

leiomyoma Menorrhagia Metrorrhagia Pelvic Pain uterine corpus leiomyoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LEIOMYOMA MENORRHAGIA METRORRHAGIA PELVIC PAIN

Contacts and locations

Locations

University of Chicago DCAM

Chicago, Illinois, 60637, United States
University of Chicago Flossmoor

Flossmoor, Illinois, 60422, United States
University of Chicago Orland Park

Orland Park, Illinois, 60462, United States
University of Chicago River East

Chicago, Illinois, 60611, United States
University of Chicago Schererville

Schererville, Indiana, 46375, United States
University of Chicago South Loop

Chicago, Illinois, 60607, United States

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