Can kidney disease weaken Kids' muscles and lungs? a study investigates
NCT ID NCT05354726
First seen Aug 20, 2026 · Last updated Aug 21, 2026 · Updated 1 time
Summary
This study looks at whether children with chronic kidney disease (CKD) have weaker muscles, poorer lung function, and lower exercise capacity compared to healthy children. Researchers will measure bone density, muscle mass, arterial stiffness, breathing strength, and physical activity in children aged 6-18 with moderate to severe CKD. The goal is to understand these relationships and potentially guide future rehabilitation programs for these children.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- No drug or device is being tested. The study involves a series of assessments including bone density scans, muscle strength tests, lung function tests, and exercise tests.
- What this could lead to
- If differences are found, it could help design rehabilitation programs to improve muscle and lung health in children with chronic kidney disease.
- What could go wrong
- This is a small observational study with only 16 participants, so results may not apply to all children with CKD. It does not test any treatment, so it cannot directly improve outcomes.
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Study facts
What this study's own registry entry says, in plain language.
- Participants
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16 people
The number who actually took part.
- Started
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Mar 2022
- Finished
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Dec 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Children who applied to Gazi University, Faculty of Medicine, Department of Pediatrics, Department of Pediatric Nephrology and met the specified inclusion criteria will be included in our study. Patients will be referred to Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Department of Physiotherapy and Rehabilitation, Cardiopulmonary Rehabilitation Unit after the routine evaluations including demographic and clinical characteristics, laboratory tests and anthropometric measurements are completed. Here, patients will be evaluated with physical therapy and rehabilitation measurement and evaluation methods such as muscle strength, exercise capacity and physical activity. The healthy control group will be formed by inviting the healthy relatives of the patients who applied to our faculty to participate in the study. After obtaining informed consent, healthy children will be evaluated.
- Ages
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6 to 18 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Group: CKD group Inclusion Criteria for Volunteers (Inclusion Criteria): * 6-18 age range, * According to the Chronic Kidney Disease Assessment and Classification Guide prepared by the National Kidney Foundation- Kidney Disease Outcomes Quality Initiative (NKF-KDOQI); Stage 2, glomerular filtration rate 60-89 ml/min/1.73 m2, Stage 3, glomerular filtration rate 30-59 ml/min/1.73 m2, Stage 4, glomerular filtration rate 15-29 ml/min/1.73 m2, * Presence of kidney transplantation was determined as inclusion criteria. Exclusion Criteria for Volunteers: * acute infection, * Ongoing dialysis, * Congenital heart disease, * Hypertension that cannot be controlled with dual antihypertensive medication, * Neurological and/or genetic musculoskeletal disease, * The presence of orthopedic and cognitive problems that prevented the tests from being performed were determined as exclusion criteria. Group: Control Group Inclusion Criteria for Control Volunteers: * Not have cardiovascular, neurological and/or genetic musculoskeletal disease * Not having orthopedic and cognitive problems that prevent testing * The patient's and/or family's willingness to participate in the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Gazi University and Hacettepe University
Ankara, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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