A spoonful of nuts? trial tests Multi-Allergy desensitization in kids

NCT ID NCT07764159

First seen Aug 13, 2026 · Last updated Aug 14, 2026 · Updated 1 time

Summary

This trial tests whether giving children with allergies to multiple nuts a daily oral immunotherapy—a mix of peanut, cashew, walnut, hazelnut, and almond proteins—can help them tolerate these foods. Children aged 1-12 with confirmed allergies to at least two of these nuts are randomly assigned to receive the immunotherapy or standard care (strict avoidance). The goal is to see if the treatment allows children to safely eat a meaningful amount of the allergens without a reaction, compared to those who just avoid the foods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Multi-food oral immunotherapy with a standardized mixture of peanut and tree nut proteins (cashew, walnut, hazelnut, almond)
What this could lead to
If successful, this approach could offer a practical way to desensitize children with multiple nut allergies, reducing the risk of severe reactions from accidental exposure.
What could go wrong
The trial is small and early, and oral immunotherapy carries risks of allergic reactions, including severe ones. It may not work for all children or all allergens.

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Conditions

The condition(s) this trial relates to.

food allergy Nut Hypersensitivity Peanut Hypersensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Allergy Unit, Department of Pulmonary Diseases, Children's Hospital in Dziekanów Leśny

    Dziekanów Leśny, Masovian Voivodeship, 05-092, Poland

  • Department of Paediatric Pulmonology and Allergology, Medical University of Warsaw

    Warsaw, Masovian Voivodeship, 02-091, Poland

  • Department of Pediatric Pulmonology, Allergology and Clinical Immunology, Institute of Pediatrics, Karol Jonscher Clinical Hospital, Poznań University of Medical Sciences

    Poznan, Greater Poland Voivodeship, 60-572, Poland

  • Department of Pediatrics, Children's Diseases Clinic, Jagiellonian University Medical Colleg, Division of Pulmonology, Allergology and Dermatology, University Children's Hospital in Kraków

    Krakow, Lesser Poland Voivodeship, 30-663, Poland

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