Mouthrinse showdown: which rinse heals gum grafts best?
NCT ID NCT07689695
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This trial tests three mouthrinses—hypochlorous acid, hyaluronic acid, and chlorhexidine—to see which helps the palate heal best after a gum graft. Fifty-four adults having gum graft surgery will rinse with one of the three solutions for 14 days. Researchers will check wound healing, pain, and bleeding over 28 days to find the most effective rinse for recovery.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hypochlorous acid, hyaluronic acid, and chlorhexidine mouthrinses
- What this could lead to
- If one mouthrinse proves superior, it could improve healing and reduce pain after gum graft surgery, making recovery more comfortable.
- What could go wrong
- This is a small, early-stage trial (54 participants) comparing existing products, so results may not apply to everyone. Any mouthrinse might cause irritation or not speed healing as hoped.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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54 people
The number who actually took part.
- Started
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Jun 2020
- Finished
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Jul 2021
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 55 years
- Sex
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Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age between 18 and 55 years. * Indication for free gingival graft surgery to increase keratinized tissue width. * Systemically healthy individuals. * Palatal donor site suitable for graft harvesting. * No history of periodontal surgery within the previous six months. * Ability and willingness to comply with postoperative instructions and follow-up visits. * Provision of written informed consent. Exclusion Criteria: * Systemic diseases that could affect wound healing. * Smoking. * Antibiotic use within the previous six months. * Pregnancy or lactation. * Known hypersensitivity to chlorhexidine, hypochlorous acid, hyaluronic acid, or any component of the study products. * Active oral infection, periodontal abscess, or poor oral hygiene. * Previous palatal surgery, mucosal lesions, anatomical limitations, or conditions affecting hemostasis at the donor site. * Inability or unwillingness to comply with the study protocol.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Van Yuzuncu Yil University Faculty of Dentistry
Van, Tuşba, 65100, Turkey (Türkiye)
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