Finding the sweet spot: safer morphine dosing for hip surgery pain

NCT ID NCT06878014

Recruiting now Symptom relief Sponsor: Medical University of Silesia Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares different doses of morphine given with spinal anesthesia during total hip replacement. The goal is to find a dose that provides good pain relief for up to 24 hours while minimizing side effects like breathing problems, nausea, and itching. About 120 adults undergoing hip replacement will take part, and their pain levels and side effects will be tracked for 48 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: morphine (given into the spinal fluid)
What this could lead to: If successful, this could help doctors choose the safest and most effective dose of spinal morphine for hip replacement pain, reducing serious side effects like breathing trouble.
What could go wrong: This is a small, early-phase trial (120 people) focused on dosing, not a new treatment. Results may not apply to all patients, and morphine still carries risks like nausea, itching, and rare breathing depression.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVERSE ANESTHESIA OUTCOME ANALGESICS, OPIOID ANESTHESIA, SPINAL TOTAL HIP REPLACEMENT

Contacts and locations

Locations

Uniwersytecki Szpital Kliniczny nr 1 im. prof. Tadeusza Sokołowskiego PUM w Szczecinie
NOT_YET_RECRUITING

Szczecin, West Pomeranian Voivodeship, 70-204, Poland
Wojewódzki Szpital Specjalistyczny nr 5 im. św. Barbary
RECRUITING

Sosnowiec, Silesian Voivodeship, 41-214, Poland
Zespół Opieki Zdrowotnej w Końskich
RECRUITING

Gmina Końskie, Świętokrzyskie Voivodeship, 26-200, Poland

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