New immunotherapy cocktails aim to tame advanced liver cancer

NCT ID NCT04524871

Recruiting now Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 28, 2026 · Updated 28 times

Summary

This study is testing several new combinations of immunotherapy drugs in people with advanced liver cancer that cannot be removed by surgery. The goal is to see if these combinations can shrink tumors or slow the disease. About 518 adults who have not had prior systemic treatment will be randomly assigned to different treatment arms. The study is flexible, allowing new drug combinations to be added as they become available.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Asan Medical Center
RECRUITING

Seoul, 5505, South Korea
Auckland City Hospital
RECRUITING

Auckland, 1023, New Zealand
Beijing Cancer Hospital
RECRUITING

Beijing, 100036, China
CHA Bundang Medical Center
ACTIVE_NOT_RECRUITING

Gyeonggi-do, 13496, South Korea
CHU Hôpitaux de Marseille
RECRUITING

Marseille, France
Centre Eugène Marquis
ACTIVE_NOT_RECRUITING

Rennes, 35042, France
Centre Georges Francois Leclerc
ACTIVE_NOT_RECRUITING

Dijon, 21079, France
Cherry Creek Medical Center
RECRUITING

Aurora, Colorado, 80045, United States
City of Hope
RECRUITING

Duarte, California, 91010, United States
Davidof Center - Rabin Medical Center
RECRUITING

Petah Tikva, 4941492, Israel
Georgetown University Medical Center
RECRUITING

Washington D.C., District of Columbia, 20007, United States
Gustave Roussy
ACTIVE_NOT_RECRUITING

Villejuif, 94800, France
Hadassah University Medical Center
RECRUITING

Jerusalem, Israel
National Cheng Kung University Hospital
RECRUITING

Tainan, 70457, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, 10002, Taiwan
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Parkland Health & Hospital System
RECRUITING

Dallas, Texas, 75235, United States
Rambam Medical Center
RECRUITING

Haifa, 3109601, Israel
Samsung Medical Center
RECRUITING

Seoul, 06351, South Korea
Sarah Cannon Research Institute / Tennessee Oncology
COMPLETED

Nashville, Tennessee, 37203, United States
Seoul National University Hospital
WITHDRAWN

Seoul, 03080, South Korea
Smilow Cancer Hospital at Yale New Haven
RECRUITING

New Haven, Connecticut, 06510, United States
Sourasky Medical Centre
RECRUITING

Tel Aviv, 64239, Israel
The University of Texas Southwestern Medical Center at Dallas
RECRUITING

Dallas, Texas, 75390, United States
UC Irvine Medical Center
RECRUITING

Costa Mesa, California, 92627, United States
UC Irvine Medical Center
RECRUITING

Orange, California, 92868, United States
UCHealth Cancer Center Pharmacy - Highlands Ranch Hospital
RECRUITING

Highlands Ranch, Colorado, 80129-6694, United States
UCLA Center for East
RECRUITING

Santa Monica, California, 90404, United States
University of California San Diego Medical Center
RECRUITING

San Diego, California, 92103, United States
University of California San Francisco Cancer Center
RECRUITING

San Francisco, California, 94115, United States
University of Colorado Hospital - Anschutz Cancer Pavilion
RECRUITING

Aurora, Colorado, 80045, United States
University of Kentucky - Markey Cancer Center
RECRUITING

Lexington, Kentucky, 40536-7001, United States
Zhongshan Hospital Fudan University
COMPLETED

Shanghai, 200032, China

Conditions

Explore the condition pages connected to this study.

ADVANCED LIVER CANCERS