Morning or evening? study tests best time for breast cancer pill to ease side effects

NCT ID NCT04864405

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether taking hormone therapy for breast cancer in the morning or evening reduces side effects and helps patients stay on treatment. 245 women with early-stage breast cancer were randomly assigned to take their medication either within an hour of waking or within an hour of bedtime. Researchers tracked changes in side effects and quality of life over 12 weeks using a standard questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

endocrine therapy (hormone-blocking medication)

What this could lead to

If successful, this could help breast cancer patients choose the best time of day to take their medication to feel better and stick with treatment.

What could go wrong

This is a small, completed Phase 4 trial focused on side effects, not on curing cancer. The results may not apply to all patients or change standard care.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • The Ottawa Hospital Cancer Centre

    Ottawa, Ontario, Canada

  • Thunder Bay Regional Health Sciences Centre

    Thunder Bay, Ontario, P7B 6V4, Canada