Could an organ rejection drug help fight brain cancer?

NCT ID NCT05236036

First seen Jan 15, 2026 · Last updated Apr 24, 2026 · Updated 14 times

Summary

This early-phase trial tests whether adding mycophenolate mofetil (a drug usually used to prevent organ rejection) to standard chemotherapy and radiation can help treat glioblastoma, an aggressive brain cancer. About 60 newly diagnosed patients will receive different doses to find the safest amount and see if the combination makes tumor cells more sensitive to treatment. The goal is to control the disease, not cure it, as ongoing management is still needed.

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Contacts and locations

Locations

  • Northwestern Lake Forest Hospital

    Lake Forest, Illinois, 60045, United States

  • Northwestern Medicine Warrenville

    Warrenville, Illinois, 60555, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

Conditions

Explore the condition pages connected to this study.