Could an antidepressant ease Post-Mastectomy pain?
NCT ID NCT06499090
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether taking mirtazapine, a common antidepressant, before and after mastectomy surgery can reduce pain and the need for strong painkillers. 62 women scheduled for mastectomy were given either mirtazapine or a placebo daily for two weeks. Researchers measured pain levels, morphine use, and recovery quality to see if mirtazapine helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Mirtazapine 30 mg tablet
What this could lead to
If it works, this could point toward a simple, low-cost way to reduce pain after mastectomy and lower the risk of long-term nerve pain.
What could go wrong
This is a very early, small study (62 people) with no long-term follow-up. The results may not apply to all patients, and mirtazapine can cause side effects like drowsiness or dizziness.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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south Egypt Cancer Institute Assiut University
Asyut, Egypt