Could an antidepressant ease Post-Mastectomy pain?
NCT ID NCT06499090
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether taking mirtazapine, a common antidepressant, before and after mastectomy surgery can reduce pain and the need for strong painkillers. 62 women scheduled for mastectomy were given either mirtazapine or a placebo daily for two weeks. Researchers measured pain levels, morphine use, and recovery quality to see if mirtazapine helps.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Mirtazapine 30 mg tablet
- What this could lead to
- If it works, this could point toward a simple, low-cost way to reduce pain after mastectomy and lower the risk of long-term nerve pain.
- What could go wrong
- This is a very early, small study (62 people) with no long-term follow-up. The results may not apply to all patients, and mirtazapine can cause side effects like drowsiness or dizziness.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
south Egypt Cancer Institute Assiut University
Asyut, Egypt
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