Blue dye may stop phantom pain after amputation
NCT ID NCT05830630
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This study tests whether adding methylene blue to a standard numbing medicine (bupivacaine) delivered through a nerve catheter can reduce pain after lower leg amputation and prevent chronic phantom limb pain. About 72 adults scheduled for above- or below-knee amputation will receive either the methylene blue mixture or a standard solution for 72 hours after surgery. Researchers will measure pain levels and track whether phantom pain develops over the following months.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- methylene blue plus bupivacaine
- What this could lead to
- If it works, this approach could offer a simple, low-cost way to reduce both immediate post-surgery pain and the risk of long-term phantom limb pain after amputation.
- What could go wrong
- This is a small, early-stage study. Methylene blue is not yet proven for this use, and there is a risk of allergic reaction or other side effects. The results may not apply to all amputation patients.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Tanta University
RECRUITINGTanta, Gharbia Governorate, 31527, Egypt
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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