Diabetes drug metformin takes on deadly brain cancer in new trial

NCT ID NCT04945148

Recruiting now Disease control Sponsor: Hopital Foch Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial is testing whether adding the diabetes drug metformin to standard radiation and chemotherapy can help people with a specific type of glioblastoma, a fast-growing brain cancer. The study will include about 64 patients whose tumors have a particular energy-making profile (OXPHOS-positive). Participants will take metformin daily alongside standard treatment, and researchers will track how long the cancer stays under control and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Metformin
What this could lead to: If it works, this could offer a new, well-tolerated treatment option for a specific subtype of glioblastoma, potentially slowing tumor growth.
What could go wrong: This is a small, early-phase trial (phase 2) with only 64 participants. The benefit may be modest or not confirmed in larger studies, and metformin may cause gastrointestinal side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

glioblastoma IDH-wildtype glioblastoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GLIOBLASTOMA, IDH-WILDTYPE

Contacts and locations

Locations

Foch Hospital
RECRUITING

Suresnes, Hauts de Seine, 92150, France
Hôpital Neurologique Pierre Wertheimer
RECRUITING

Bron, Lyon, 69500, France
Istituto Nazionale Carlo Besta
NOT_YET_RECRUITING

Milan, Milano, 20131, Italy
Pitié Salpêtrière Hospital
RECRUITING

Paris, PARIS, 75013, France
Saint Louis Hospital
RECRUITING

Paris, Paris, 75010, France
Spidali Riuniti Di Livorno
NOT_YET_RECRUITING

Livorno, Toscana Nord Ouest, 57100, Italy
Timone Hospital
RECRUITING

Marseille, Marseille, 13354, France

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