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Which numbing drug gets feet ready for surgery faster?

NCT ID NCT05425979

Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 18, 2026 · Last updated Sep 18, 2026

Summary

Researchers at Mayo Clinic are comparing two local anesthetics, mepivacaine and bupivacaine, for ultrasound-guided ankle blocks used during foot surgery. Both drugs are already standard for this purpose, and the trial asks whether mepivacaine numbs the foot just as reliably but with a faster onset. Fifty adults having foot surgery receive one of the two drugs injected near the ankle nerves, and researchers time how long it takes for the block to work. They also track block failures, pain scores after surgery, and any side effects.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
mepivacaine and bupivacaine, two local anesthetics injected near the ankle nerves
What this could lead to
If mepivacaine numbs the foot as well as bupivacaine but faster, surgical teams could start foot operations sooner and use one standard numbing drug for ankle blocks.
What could go wrong
This is a small, single-center study of 50 people, so its results may not apply to every patient or hospital. Ankle blocks can fail and require extra pain medicine or general anesthesia, and both drugs carry small risks of allergic reaction or nerve irritation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age greater than or equal to 18 years old. * Patients who provide informed consent to participate. * Patients undergoing foot surgery who require a peripheral nerve block of the ankle as primary anesthesia. * ASA (American Society of Anesthesiology) Physical Status Classification I - III. Exclusion Criteria: * Inability to consent. * Allergy to local anesthetic. * Infection at site of injection. * Pregnancy. * Coagulopathy. * Hepatic or renal failure. * Preexisting neuropathy in operative limb. * Planned spinal anesthetic or general anesthesia.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankle block Foot surgery

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

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Contacts and locations

Locations

  • Mayo Clinic in Rochester

    Rochester, Minnesota, 55905, United States

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