Which pain shot works best after ankle surgery? new study aims to find out
NCT ID NCT04575688
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two standard pain-relief methods after ankle or hindfoot surgery: a shot of Exparel around the surgical area versus a nerve block with bupivacaine behind the knee. About 100 adults having certain foot or ankle procedures will be enrolled. The goal is to see which approach provides better pain control and allows patients to move their toes sooner.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Exparel (bupivacaine liposome injectable suspension) and bupivacaine
- What this could lead to
- If one method works better, it could improve pain control and reduce the need for narcotics after ankle or foot surgery.
- What could go wrong
- This is a small, early-phase study (100 people) comparing two already-used methods, so it may not show a clear winner or change practice widely.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
A
Germantown, Tennessee, 38138, United States
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