Which pain shot works best after ankle surgery? new study aims to find out
NCT ID NCT04575688
First seen Jan 11, 2026 · Last updated Jun 23, 2026 · Updated 26 times
Summary
This study compares two standard pain-relief methods after ankle or hindfoot surgery: a shot of Exparel around the surgical area versus a nerve block with bupivacaine behind the knee. About 100 adults having certain foot or ankle procedures will be enrolled. The goal is to see which approach provides better pain control and allows patients to move their toes sooner.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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A
Germantown, Tennessee, 38138, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Exparel (bupivacaine liposome injectable suspension) and bupivacaine
What this could lead to
If one method works better, it could improve pain control and reduce the need for narcotics after ankle or foot surgery.
What could go wrong
This is a small, early-phase study (100 people) comparing two already-used methods, so it may not show a clear winner or change practice widely.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.