Stem cells vs. platelets: which boosts knee repair best?
NCT ID NCT04775004
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares two biologic techniques used during meniscal tear surgery: a bone marrow venting procedure (BMVP) that releases stem cells, and a platelet-rich plasma (PRP) injection from the patient's own blood. About 146 participants aged 16 and older with specific meniscal tears will be randomly assigned to one method. The goal is to see which approach leads to better knee function and fewer re-tears over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Bone marrow venting procedure (BMVP) and Platelet Rich Plasma (PRP)
- What this could lead to
- If successful, this could show which biologic augmentation method better improves meniscal repair success and reduces re-tear rates.
- What could go wrong
- This is a relatively small, early-stage comparative trial without a placebo group, so results may not be definitive or widely applicable.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Chicago Medicine
Chicago, Illinois, 60637, United States
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University of Florida
Gainesville, Florida, 32611, United States
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Wake Forest University Health Sciences
Winston-Salem, North Carolina, 27157, United States
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