New hope for Tough-to-Treat lymphoma: Two-Drug combo enters Mid-Stage trial

NCT ID NCT06534437

Recruiting now Disease control Sponsor: Ryvu Therapeutics SA Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial is testing a new drug called MEN1703, both alone and combined with another drug called glofitamab, in 178 adults with aggressive B-cell non-Hodgkin lymphoma that has come back or not responded to at least two prior treatments. The study aims to see if the drugs are safe and can shrink tumors. Participants are split into two groups: those who have not tried a certain type of immunotherapy, and those who have exhausted all standard options.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: MEN1703 (Dapolsertib hydrochloride) and Glofitamab
What this could lead to: If successful, this combination could offer a new treatment option for patients with aggressive B-cell lymphoma who have run out of standard therapies.
What could go wrong: This is an early Phase 2 trial with a small number of participants. The drugs may cause side effects, and it is not yet known if they will work better than existing treatments.

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Conditions

The condition(s) this trial relates to.

Aggression aggressive B-cell non-Hodgkin lymphoma B-cell non-Hodgkin lymphoma non-Hodgkin lymphoma Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-HODGKIN LYMPHOMA,B CELL

Contacts and locations

Locations

APHP - Hôpital Pitié-Salpêtrière
RECRUITING

Paris, 75651, France
Aidport Sp. z o.o.
RECRUITING

Skórzewo, Poland
Beatson West of Scotland Cancer Centre
RECRUITING

Glasgow, United Kingdom
CHU Montpellier - Hôpital Saint Eloi
RECRUITING

Montpellier, 34490, France
CHU de Bordeaux - Hôpital Haut-Lévêque
RECRUITING

Pessac, 33600, France
CHU de Lille - Hôpital Claude Huriez
RECRUITING

Lille, France
CHU de Limoges - CHU Dupuytren
RECRUITING

Limoges, 87042, France
Centre Hospitalier Le Mans
RECRUITING

Le Mans, 72037, France
Clinica Universidad De Navarra
RECRUITING

Madrid, 28027, Spain
Clinica Universidad De Navarra
RECRUITING

Pamplona, 31008, Spain
Hospices Civils De Lyon - Hôpital Lyon Sud
RECRUITING

Lyon, 69310, France
Hospital Clínico Uni versitario Virgen de la Arrixaca
NOT_YET_RECRUITING

Murcia, 30120, Spain
Hospital Universitari Vall D Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario De Navarra
RECRUITING

Pamplona, 31008, Spain
Hospital Universitario De Salamanca
RECRUITING

Salamanca, 37007, Spain
Hospital Universitario Miguel Servet
NOT_YET_RECRUITING

Zaragoza, Spain
Hospital Universitario Puerta de Hierro Majadahonda
NOT_YET_RECRUITING

Madrid, Spain
Hospital Universitario Virgen De La Macarena
RECRUITING

Seville, 41009, Spain
IN-VIVO Bydgoszcz Sp. z o.o.
RECRUITING

Bydgoszcz, Poland
Klinika Hematologii I Transplantologii Uck
NOT_YET_RECRUITING

Gdansk, Poland
Lux Med Onkologia Sp. z o.o.
RECRUITING

Warsaw, Poland
MD Anderson Cancer Center
RECRUITING

Madrid, 28033, Spain
Narodowy Instytut Onkologii im. Marii Skłodowskiej Curie, Państwowy Instytut Badawczy
RECRUITING

Gliwice, Poland
Plymouth Hospitals NHS Trust
RECRUITING

Plymouth, United Kingdom
Pratia Hematologia Sp. z o.o.
RECRUITING

Katowice, Poland
Pratia MCM Kraków
RECRUITING

Krakow, Poland
SP ZOZ Szpital Uniwersytecki w Krakowie
NOT_YET_RECRUITING

Krakow, Poland
St George's Hospital
RECRUITING

Tooting, United Kingdom
Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko-Mazurskim Centrum Onkologii w Olsztynie
RECRUITING

Olsztyn, Poland
Szpitale Pomorskie Sp. z o.o.
RECRUITING

Gdynia, Poland
The Christie NHS Foundation Trust
RECRUITING

Manchester, United Kingdom
The Royal Marsden Hospital
NOT_YET_RECRUITING

London, United Kingdom
The Royal Marsden Hospital
NOT_YET_RECRUITING

Sutton, United Kingdom
Wojewódzki Szpital Specjalistyczny w Białej Podlaskiej
RECRUITING

Biała Podlaska, Poland
Wojewódzki Szpital Zespolony im. L. Rydygiera w Toruniu
RECRUITING

Torun, Poland
Wojskowy Instytut Medyczny - Państwowy Instytut Badawczy
RECRUITING

Warsaw, Poland

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