New hope for Tough-to-Treat lymphoma: Two-Drug combo enters Mid-Stage trial
NCT ID NCT06534437
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 trial is testing a new drug called MEN1703, both alone and combined with another drug called glofitamab, in 178 adults with aggressive B-cell non-Hodgkin lymphoma that has come back or not responded to at least two prior treatments. The study aims to see if the drugs are safe and can shrink tumors. Participants are split into two groups: those who have not tried a certain type of immunotherapy, and those who have exhausted all standard options.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MEN1703 (Dapolsertib hydrochloride) and Glofitamab
What this could lead to
If successful, this combination could offer a new treatment option for patients with aggressive B-cell lymphoma who have run out of standard therapies.
What could go wrong
This is an early Phase 2 trial with a small number of participants. The drugs may cause side effects, and it is not yet known if they will work better than existing treatments.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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APHP - Hôpital Pitié-Salpêtrière
RECRUITINGParis, 75651, France
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Aidport Sp. z o.o.
RECRUITINGSkórzewo, Poland
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Beatson West of Scotland Cancer Centre
RECRUITINGGlasgow, United Kingdom
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CHU Montpellier - Hôpital Saint Eloi
RECRUITINGMontpellier, 34490, France
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CHU de Bordeaux - Hôpital Haut-Lévêque
RECRUITINGPessac, 33600, France
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CHU de Lille - Hôpital Claude Huriez
RECRUITINGLille, France
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CHU de Limoges - CHU Dupuytren
RECRUITINGLimoges, 87042, France
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Centre Hospitalier Le Mans
RECRUITINGLe Mans, 72037, France
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Clinica Universidad De Navarra
RECRUITINGMadrid, 28027, Spain
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Clinica Universidad De Navarra
RECRUITINGPamplona, 31008, Spain
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Hospices Civils De Lyon - Hôpital Lyon Sud
RECRUITINGLyon, 69310, France
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Hospital Clínico Uni versitario Virgen de la Arrixaca
NOT_YET_RECRUITINGMurcia, 30120, Spain
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Hospital Universitari Vall D Hebron
RECRUITINGBarcelona, 08035, Spain
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Hospital Universitario De Navarra
RECRUITINGPamplona, 31008, Spain
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Hospital Universitario De Salamanca
RECRUITINGSalamanca, 37007, Spain
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Hospital Universitario Miguel Servet
NOT_YET_RECRUITINGZaragoza, Spain
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Hospital Universitario Puerta de Hierro Majadahonda
NOT_YET_RECRUITINGMadrid, Spain
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Hospital Universitario Virgen De La Macarena
RECRUITINGSeville, 41009, Spain
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IN-VIVO Bydgoszcz Sp. z o.o.
RECRUITINGBydgoszcz, Poland
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Klinika Hematologii I Transplantologii Uck
NOT_YET_RECRUITINGGdansk, Poland
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Lux Med Onkologia Sp. z o.o.
RECRUITINGWarsaw, Poland
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MD Anderson Cancer Center
RECRUITINGMadrid, 28033, Spain
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Narodowy Instytut Onkologii im. Marii Skłodowskiej Curie, Państwowy Instytut Badawczy
RECRUITINGGliwice, Poland
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Plymouth Hospitals NHS Trust
RECRUITINGPlymouth, United Kingdom
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Pratia Hematologia Sp. z o.o.
RECRUITINGKatowice, Poland
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Pratia MCM Kraków
RECRUITINGKrakow, Poland
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SP ZOZ Szpital Uniwersytecki w Krakowie
NOT_YET_RECRUITINGKrakow, Poland
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St George's Hospital
RECRUITINGTooting, United Kingdom
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Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko-Mazurskim Centrum Onkologii w Olsztynie
RECRUITINGOlsztyn, Poland
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Szpitale Pomorskie Sp. z o.o.
RECRUITINGGdynia, Poland
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The Christie NHS Foundation Trust
RECRUITINGManchester, United Kingdom
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The Royal Marsden Hospital
NOT_YET_RECRUITINGLondon, United Kingdom
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The Royal Marsden Hospital
NOT_YET_RECRUITINGSutton, United Kingdom
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Wojewódzki Szpital Specjalistyczny w Białej Podlaskiej
RECRUITINGBiała Podlaska, Poland
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Wojewódzki Szpital Zespolony im. L. Rydygiera w Toruniu
RECRUITINGTorun, Poland
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Wojskowy Instytut Medyczny - Państwowy Instytut Badawczy
RECRUITINGWarsaw, Poland
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