New liquid biopsy could spot hidden brain lymphoma

NCT ID NCT06090162

Ongoing Diagnosis Sponsor: Swiss Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a liquid biopsy (a simple test that checks for cancer DNA in spinal fluid) can better detect and monitor brain involvement in people with high-risk B-cell non-Hodgkin lymphoma. Researchers will compare this new method to standard tests in 64 newly diagnosed patients. If successful, it could help doctors decide who needs stronger treatment to prevent or manage lymphoma in the brain.

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma Burkitt lymphoma diffuse large B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement mantle cell lymphoma non-Hodgkin lymphoma primary central nervous system lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-HODGKIN LYMPHOMA,B CELL

Contacts and locations

Locations

CHUV - Départment d'oncologie

Lausanne, 1011, Switzerland
Hopitaux Universitaire de Genève (HUG)

Geneva, 1205, Switzerland
Hôpital Fribourgeois - Hôpital Cantonal

Fribourg, 1708, Switzerland
Hôpital du Valais, Hôpital de Sion

Sion, 1951, Switzerland
Inselspital Bern - Universitätsklinik für Medizinische Onkologie

Bern, 3010, Switzerland
Istituto Oncologico della Svizzera Italiana (IOSI)

Bellinzona, 6500, Switzerland
Kantonspital Aarau

Aarau, 5001, Switzerland
Kantonsspital Baselland

Liestal, 4410, Switzerland
Kantonsspital Graubünden

Chur, 7000, Switzerland
Kantonsspital Münsterlingen

Münsterlingen, 8596, Switzerland
Kantonsspital St. Gallen

Sankt Gallen, 9007, Switzerland
Klinik für Hämatologie und Onkologie Hirslanden Zürich

Zurich, 8032, Switzerland
Stadtspital Triemli Zürich

Zurich, 8063, Switzerland
Universitätsspital Basel

Basel, 4056, Switzerland

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