New liquid biopsy could spot hidden brain lymphoma

NCT ID NCT06090162

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether a liquid biopsy (a simple test that checks for cancer DNA in spinal fluid) can better detect and monitor brain involvement in people with high-risk B-cell non-Hodgkin lymphoma. Researchers will compare this new method to standard tests in 64 newly diagnosed patients. If successful, it could help doctors decide who needs stronger treatment to prevent or manage lymphoma in the brain.

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Conditions

The condition(s) this trial relates to.

B-cell non-Hodgkin lymphoma Burkitt lymphoma diffuse large B-cell lymphoma high grade B-cell lymphoma with MYC and/ or BCL2 and/or BCL6 rearrangement mantle cell lymphoma non-Hodgkin lymphoma primary central nervous system lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHUV - Départment d'oncologie

    Lausanne, 1011, Switzerland

  • Hopitaux Universitaire de Genève (HUG)

    Geneva, 1205, Switzerland

  • Hôpital Fribourgeois - Hôpital Cantonal

    Fribourg, 1708, Switzerland

  • Hôpital du Valais, Hôpital de Sion

    Sion, 1951, Switzerland

  • Inselspital Bern - Universitätsklinik für Medizinische Onkologie

    Bern, 3010, Switzerland

  • Istituto Oncologico della Svizzera Italiana (IOSI)

    Bellinzona, 6500, Switzerland

  • Kantonspital Aarau

    Aarau, 5001, Switzerland

  • Kantonsspital Baselland

    Liestal, 4410, Switzerland

  • Kantonsspital Graubünden

    Chur, 7000, Switzerland

  • Kantonsspital Münsterlingen

    Münsterlingen, 8596, Switzerland

  • Kantonsspital St. Gallen

    Sankt Gallen, 9007, Switzerland

  • Klinik für Hämatologie und Onkologie Hirslanden Zürich

    Zurich, 8032, Switzerland

  • Stadtspital Triemli Zürich

    Zurich, 8063, Switzerland

  • Universitätsspital Basel

    Basel, 4056, Switzerland