Can a chemo drug keep sarcoma at bay? new trial aims to find out

NCT ID NCT06981637

Recruiting now Disease control Sponsor: National Health Research Institutes, Taiwan Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 02, 2026 · Updated 2 times

Summary

This Phase 2 trial tests whether a chemotherapy drug called pegylated liposomal doxorubicin (PLD) can help people with advanced soft tissue sarcoma live longer without their cancer growing. Participants who have already responded to standard chemotherapy will either receive PLD every 4 weeks for up to 12 cycles or be closely monitored without treatment. The study aims to see if maintenance therapy delays cancer progression compared to active surveillance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pegylated liposomal doxorubicin (a chemotherapy drug)
What this could lead to: If successful, this could provide a new maintenance option to delay cancer progression in advanced soft tissue sarcoma patients who have already responded to initial chemotherapy.
What could go wrong: This is a small Phase 2 trial with only 81 participants, so results may not be conclusive. The drug can cause side effects like heart damage or low blood counts, and it may not improve survival.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

soft tissue sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVANCED SOFT TISSUE SARCOMA

Contacts and locations

Locations

Chang Gung Memorial Hospital
RECRUITING

Kaohsiung City, Taiwan
China Medical University Hospital
RECRUITING

Taichung, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital,
RECRUITING

Kaohsiung City, Taiwan
National Cheng Kung University Hospital
RECRUITING

Tainan, Taiwan
National Taiwan University Hospital
RECRUITING

Taipei, Taiwan
Taipei Veterans General Hospital
RECRUITING

Taipei, Taiwan
Tri-Service General Hospital
RECRUITING

Taipei, Taiwan

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