Face-Off: natural blood injection vs drug for stubborn melasma

NCT ID NCT07540702

Recruiting now Symptom relief Sponsor: Kasr El Aini Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether injecting platelet-rich fibrin (made from your own blood) works better than tranexamic acid for treating facial melasma, a common skin condition causing dark patches. Twenty-one women with melasma will receive one treatment on each side of their face. The goal is to see which reduces pigmentation more safely over five sessions.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: platelet-rich fibrin (i-PRF) and tranexamic acid
What this could lead to: If i-PRF works better or as well as tranexamic acid, it could offer a new, natural treatment option for melasma with fewer side effects.
What could go wrong: This is a small, early-stage study with only 21 participants. Results may not apply to everyone, and both treatments may cause temporary redness, swelling, or bruising.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Melanosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FACIAL MELASMA MELASMA

Contacts and locations

Locations

Kasr El Aini Hospital
RECRUITING

Cairo, Cairo Governorate, 11555, Egypt

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