Face-Off: natural blood injection vs drug for stubborn melasma
NCT ID NCT07540702
First seen Jun 24, 2026 · Last updated Jun 24, 2026
Summary
This study tests whether injecting platelet-rich fibrin (made from your own blood) works better than tranexamic acid for treating facial melasma, a common skin condition causing dark patches. Twenty-one women with melasma will receive one treatment on each side of their face. The goal is to see which reduces pigmentation more safely over five sessions.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Kasr El Aini Hospital
RECRUITINGCairo, Cairo Governorate, 11555, Egypt
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
platelet-rich fibrin (i-PRF) and tranexamic acid
What this could lead to
If i-PRF works better or as well as tranexamic acid, it could offer a new, natural treatment option for melasma with fewer side effects.
What could go wrong
This is a small, early-stage study with only 21 participants. Results may not apply to everyone, and both treatments may cause temporary redness, swelling, or bruising.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.