Cure My Disease

Don't miss your cure!

 Log in / Sign up

Brain metastases trial: can adding radiation boost immunotherapy?

NCT ID NCT03340129

Recruiting now Disease control Sponsor: Melanoma Institute Australia Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for people with stage IV melanoma that has spread to the brain. It compares two treatments: a combination of two immunotherapy drugs (ipilimumab and nivolumab) alone, or the same drugs plus precise, targeted radiation to the brain tumors. The goal is to see if adding radiation helps control the disease and reduces the chance of dying from neurological causes. About 218 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Ipilimumab (Yervoy) and nivolumab (Opdivo) with or without stereotactic radiotherapy
What this could lead to
If it works, this could show that adding precise radiation to immunotherapy helps control melanoma brain metastases better than immunotherapy alone.
What could go wrong
This is a phase 2 trial, so results are still early. The combination may cause more side effects, and it's unclear if it will improve survival or just delay progression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MELANOMA STAGE IV are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

brain cancer melanoma metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA STAGE IV

Contacts and locations

Study contacts

  • Contact

    Email: •••••@•••••

Locations

  • Alfred Hospital

    RECRUITING

    Melbourne, Victoria, 3004, Australia

  • Calvary Mater NewcastleHospital

    RECRUITING

    Waratah, New South Wales, 2298, Australia

  • Melanoma Institute Australia

    RECRUITING

    Wollstonecraft, New South Wales, 2065, Australia

  • Oslo Univesity Hospital Radiumhospitalet

    TERMINATED

    Oslo, Oslo, 0379, Norway

  • Peter MacCallum Cancer Centre

    RECRUITING

    East Melbourne, Victoria, 3002, Australia

  • Princess Alexandra Hospital

    RECRUITING

    Woolloongabba, Queensland, 4102, Australia

  • Royal Adelaide Hospital

    RECRUITING

    Adelaide, South Australia, 5000, Australia

  • Sir Charles Gairdner Hosptial

    RECRUITING

    Perth, Western Australia, 6009, Australia

  • Westmead Hospital

    RECRUITING

    Sydney, New South Wales, 2145, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.