Vitamin B12 trial aims to stop Chemo's painful side effect

NCT ID NCT07423390

Recruiting now Prevention Sponsor: Qinghai Red Cross Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether taking mecobalamin (a form of vitamin B12) can prevent or reduce nerve damage caused by taxane chemotherapy. About 326 adults with various solid tumors will take mecobalamin tablets or receive no preventive treatment during their chemo. The goal is to see if fewer people develop numbness, tingling, or pain in their hands and feet.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mecobalamin (a form of vitamin B12)
What this could lead to: If it works, this could provide a simple, low-cost way to prevent painful nerve damage during chemotherapy.
What could go wrong: This is a single-center trial, and the benefit may be modest or not confirmed. Mecobalamin is generally safe but may not prevent all nerve symptoms.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neoplasm peripheral nervous system disorder chemotherapy-induced neuropathy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PERIPHERAL NEUROPATHY DUE TO CHEMOTHERAPY PERIPHERAL NEUROPATHY, CHEMOTHERAPY-INDUCED

Contacts and locations

Locations

Affiliated Cancer Hospital of Shandong First Medical University (Shandong Cancer Hospital)
NOT_YET_RECRUITING

Jinan, Shandong, China
Affiliated Hospital of Qinghai University
NOT_YET_RECRUITING

Xining, Qinghai, China
Beijing Chaoyang Sanhuan Cancer Hospital
RECRUITING

Beijing, China
Qinghai Red Cross Hospital
RECRUITING

Xining, Qinghai, China

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