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The hidden force of a ventilator: does more power mean more risk?

NCT ID NCT07836153

Knowledge-focused Sponsor: Zagazig University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 23, 2026 · Last updated Sep 24, 2026 · Updated 1 time

Summary

Researchers at Zagazig University are observing 116 critically ill adults who need a breathing machine in the surgical intensive care unit. The study tracks the mechanical power the ventilator delivers during the first 72 hours and compares it with who survives 28 days later. They also measure driving pressure, plateau pressure, ventilator-free days, and how long patients stay in the ICU. The goal is to understand whether higher ventilator energy is linked to worse outcomes.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If a clear link emerges, doctors could adjust ventilator settings to lower the energy delivered to fragile lungs and possibly improve survival for critically ill patients.
What could go wrong
This is an observational study, so it can show a pattern but cannot prove that mechanical power causes deaths or that changing it saves lives. Findings from one surgical ICU may not apply elsewhere.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 116 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Aug 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients requiring invasive mechanical ventilation and admitted to the Surgical Intensive Care Unit at Zagazig University Hospitals.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years. * Both sexes. * Patients requiring invasive controlled mechanical ventilation in the ICU and expected to require mechanical ventilation for at least 72 hours. * Enrollment within the first 8 hours after initiation of invasive mechanical ventilation. * Acceptance and written informed consent from a first-degree relative. Exclusion Criteria: * Predominant spontaneous breathing or weaning modes during the first 48 hours. * Severe hemodynamic instability precluding standardized measurements. * Prolonged mechanical ventilation prior to ICU admission. * Pregnancy. * Chest trauma.

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Conditions

The condition(s) this trial relates to.

acute respiratory distress syndrome Ventilator-Induced Lung Injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARDS Icu mortality (survival rate) Mechanical ventilation complication Ventilator induced lung injury

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Surgical Intensive Care Unit, Zagazig University Hospitals

    Zagazig, Sharqia Province, Egypt

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