Experimental drug combo targets Hard-to-Treat sarcomas

NCT ID NCT03425279

Completed Disease control Sponsor: BioAtla, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a new drug called mecbotamab vedotin, alone or with the immunotherapy nivolumab, in 245 adults and teens aged 12+ with advanced solid tumors, including sarcomas. The goal was to check safety and see if the drug shrinks tumors. The trial is now complete, and results will help decide if further testing is needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: mecbotamab vedotin (a targeted drug) and nivolumab (an immunotherapy)
What this could lead to: If successful, this could provide a new treatment option for people with advanced sarcomas that are hard to treat.
What could go wrong: This is an early-phase trial (Phase 1/2), so the drug may not work or could have serious side effects. Results are not yet confirmed for broader use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dermatofibrosarcoma protuberans myxofibrosarcoma neoplasm undifferentiated pleomorphic sarcoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYXOFIBROSARCOMA UNDIFFERENTIATED PLEOMORPHIC SARCOMA

Contacts and locations

Locations

Abramson Cancer Center at Pennsylvania Hospital

Philadelphia, Pennsylvania, 19106, United States
Chang Gung Memorial Hospital

Taoyuan, Taiwan
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Research Institute

Washington D.C., District of Columbia, 20010, United States
Columbia University

New York, New York, 10032, United States
Comprehensive Cancer Center of Nevada

Las Vegas, Nevada, 89169, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Duke Cancer Institute

Durham, North Carolina, 27710, United States
Froedtert Hospital and the Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
MD Anderson Cancer Center

Houston, Texas, 77030, United States
Mary Crowley Cancer Research

Dallas, Texas, 75230, United States
Massachusetts General Hospital

Boston, Massachusetts, 02114, United States
Memorial Sloan Kettering

New York, New York, 10065, United States
Moffitt Cancer Center

Tampa, Florida, 33612, United States
National Cheng Kung University Hospital

Tainan, Taiwan
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Northwestern University

Chicago, Illinois, 60611, United States
Norton Cancer Institute

Louisville, Kentucky, 40202, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Precision NextGen Oncology

Los Angeles, California, 90212, United States
Prince of Wales Hospital

Hong Kong, Hong Kong
Queen Mary Hospital

Hong Kong, Hong Kong
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Sarah Cannon Research Institute at Health One

Denver, Colorado, 80218, United States
Seattle Cancer Care Alliance

Seattle, Washington, 98109, United States
Taipei Veterans General Hospital

Taipei, Taiwan
Tennessee Oncology

Nashville, Tennessee, 37203, United States
The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
The Christ Hospital

Cincinnati, Ohio, 45219, United States
The Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
The University of Arizona Cancer Center

Tucson, Arizona, 85724, United States
Tower Hematology Oncology Medical Group

Los Angeles, California, 90048, United States
UCSF Medical Center - Cancer Immunotherapy Clinic (CIC)

San Francisco, California, 94158, United States
USC Norris Comprehensive Cancer Center

Los Angeles, California, 90033, United States
University Hospitals Seidman Cancer Center

Cleveland, Ohio, 44106, United States
University of Colorado

Aurora, Colorado, 80045, United States
University of Utah - Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States
Vanderbilt Ingram Cancer Center

Nashville, Tennessee, 37232, United States
Wake Forest Baptist Health

Winston-Salem, North Carolina, 27157, United States
Washington University School of Medicine - Siteman Cancer Center

St Louis, Missouri, 63110, United States

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